Functional
nanomaterials are one of the potential carriers for
drug delivery, whereas there are many prerequisites for this purpose.
The carrier should be monodispersed, be fluorescent, and have a proper
nanostructure to keep/release drug molecules to achieve controlled
release, although preparing a nanomaterial which fulfills all the
demands is still very challenging. In this paper, we show the preparation
of monodispersed nanoporous amorphous titania submicron particles
with fluorescent property. They adsorb a model drug moleculeibuprofenwith
their surface coverage up to 100%. Such a perfect loading does not
decrease the fluorescent intensity because of any quenching effects
but even maximize it. We also demonstrate the release behavior of
IBU into simulated body fluid. Interestingly, the present carrier
releases most of IBU in 6 h, whereas that modified with the polyethylene
glycol moiety takes 48 h to finish releasing IBU, indicating its potential
for controlled release applications.
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