Preparation of Monodispersed Nanoporous Eu(III)/Titania Loaded with Ibuprofen: Optimum Loading, Luminescence, and Sustained Release

Abstract

Functional nanomaterials are one of the potential carriers for drug delivery, whereas there are many prerequisites for this purpose. The carrier should be monodispersed, be fluorescent, and have a proper nanostructure to keep/release drug molecules to achieve controlled release, although preparing a nanomaterial which fulfills all the demands is still very challenging. In this paper, we show the preparation of monodispersed nanoporous amorphous titania submicron particles with fluorescent property. They adsorb a model drug moleculeibuprofenwith their surface coverage up to 100%. Such a perfect loading does not decrease the fluorescent intensity because of any quenching effects but even maximize it. We also demonstrate the release behavior of IBU into simulated body fluid. Interestingly, the present carrier releases most of IBU in 6 h, whereas that modified with the polyethylene glycol moiety takes 48 h to finish releasing IBU, indicating its potential for controlled release applications.

Precipitative Coating of Calcium Phosphate on Microporous Silica–Titania Hybrid Particles in Simulated Body Fluid

“…Various nanomaterials composed of bioinert ceramics have been synthesized for use as artificial joints, implants, and drug delivery system (DDS) carriers [1,2]. In these applications, a DDS carrier needs to fulfill many requisites, including not only the inherent biocompatibility of bioceramic-based materials but also other properties including being of a uniform shape, size, and size distribution and possessing high affinity for aqueous media in order to form a stable suspension [3][4][5]. A sol-gel method based on the hydrolysis and condensation of a metal alkoxide has been used to synthesize a variety of biocompatible metal oxide nanoparticles with controlled morphologies, for which titania and silica have been extensively studied [6][7][8].…”