The interaction of Pt with CeO(2) layers was investigated by using photoelectron spectroscopy. The 30 nm thick Pt doped CeO(2) layers were deposited simultaneously by rf-magnetron sputtering on a Si(001) substrate, multiwall carbon nanotubes (CNTs) supported by a carbon diffusion layer of a polymer membrane fuel cell and on CNTs grown on the silicon wafer by the CVD technique. The synchrotron radiation X-ray photoelectron spectra showed the formation of cerium oxide with completely ionized Pt(2+,4+) species, and with the Pt(2+)/Pt(4+) ratio strongly dependent on the substrate. The TEM and XRD study showed the Pt(2+)/Pt(4+) ratio is dependent on the film structure.

IntroductionValidation of analytical procedure is the process for proving that an analytical procedure is suitable for its intended purpose. Results obtained from method validation study can be used to judge the quality, reliability and consistency of analytical results. AbstractHPLC analysis is the critical factors in the drug developing process, and it is important to ensure the reliability of the analytical procedure to obtain meaningful data. The International Conference on Harmonization (ICH) has recognized the importance of validation concerning analytical procedures, and issued the guideline on Validation of Analytical Procedures (Q2) as a frame work for the validation study. This report complements the ICH guideline Q2, and provides practicable means for validation study focusing on the analyses by HPLC.

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