[3][4][5][6][7][8][9][10], were tested for agonistic activity as well as for their ability to antagonize the myotropic actions of NKB, neurokinin A, substance P, physalaemin and eledoisin in isolated guinea-pig ileum, guinea-pig urinary bladder, rat duode num, rat vas deferens and rat portal vein.[GIy6]-NKB [3][4][5][6][7][8][9][10] in the guinea-pig ileum and rat portal vein and [Arg3, D-Ala6]-NKB [3][4][5][6][7][8][9][10] in the guinea-pig ileum were found to be the first specific and competitive antagonists against NKB.
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