Hypocalcemic effect of acetylsalicylic acid in rats.

Ueno, Koichi; Masumura, Hidemi; Kitagawa, Haruo; Naminohira, Shigeru; Saito, Haruo; Sakai, Takeshi

doi:10.1248/bpb1978.4.229

Cited by 9 publications

(1 citation statement)

References 4 publications

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“…In accordance with the present results, significant drop in Ca by irradiation was attributed to inhibitory effect of ionizing radiation on the Ca channels (Nunia et al, 2007). A correlation exists between embryoliththality and tratogenicity with decrease in Ca level (Ueno et al, 1981). Aldosterone, opens voltage dependant Ca channels, promotes the reabsorption of Na in the distal tubules of the kidney resulting in K secretion along with Na retention, which controls the circulating blood volume (Cartledge and Lawson, 2000).…”

Section: Discussionsupporting

confidence: 88%

Modulation of Radiation Injury in Pregnant Rats by Bone Marrow Transplantation

Hussein

Rabu

2011

Egypt. J. Rad.Sci.

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HIS WORK aims to point out the influence of bone marrow transplantation (BMT) in protection of irradiated pregnant rats and suppression of oxidative stress. BMT was administered to rats, 1 h post gamma irradiation at the dose level of 2 Gy given at the 7th or 14th day of gestation. Rats were examined after 20 days from gestation to detect the physiological parameters of the mother and number of implantation sites and resorptions as well as length of foetuses and tails. Pregnant rats irradiated at the 7 th and 14 th day of gestation showed reduction in live foetuses and length of foetuses and their tails and significant decrease in erythrocytes (RBCs), leucocytes (WBCs), haemoglobin content (Hb), and hematocrite percentage (Ht). Irradiation-induced an elevation in aldosteron and a drop in calcium (Ca). Glutathione levels showed significant decreases in blood while the content of serum thiobarbituric acid reactive substance (TBARS) showed significant increases. Lipid profile exhibited an increase in the concentrations of total cholesterol (TC), triglycerides (TG) and low lipoproteins cholesterol (LDL-C) with a significant decrease in high lipoproteins cholesterol (HDL-C) in both groups. BMT to irradiated pregnant rats induced significant amelioration in radiation-induced changes. BMT was shown to be effective in reducing physiological disorders and oxidative stress in pregnant rats reflected on minimizing embryonic injuries.

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Section: Discussionsupporting

confidence: 88%

Modulation of Radiation Injury in Pregnant Rats by Bone Marrow Transplantation

Hussein

Rabu

2011

Egypt. J. Rad.Sci.

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Differential Uptake of Salicylate in Serum, Cerebrospinal Fluid, and Perilymph

Jastreboff¹,

Hansen²,

Sasaki³

et al. 1986

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\After intraperitoneal administration of salicylate in anesthetized rats and guinea pigs, we found that salicylate levels in perilymph (PL) are closely related to both drug levels in cerebrospinal fluid (CSF) and in serum, with higher levels systematically observed in PL than in CSF. Further analysis suggests that salicylate is not passively transported into PL across CSF but, rather, is transported from blood directly to PL. The time course of salicylate uptake in rats reveals maximum levels at 1\m=1/2\hours (serum) and two to four hours (CSF and PL). On the other hand, salicylate uptake into serum and CSF of guinea pigs exhibits a longer time course, with maximum levels reached at four hours (serum) and five hours (CSF). These data, not previously available, are basic to our understanding of salicylate-related auditory effects.

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Pigmentation, Anesthesia, Behavioral Factors, and Salicylate Uptake

Jastreboff

Issing²,

Brennan³

et al. 1988

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\In four experiments, 54 pigmented rats were used to examine the time course of sodium salicylate uptake in serum, cerebrospinal fluid, and perilymph. Subjects were tested under sodium pentobarbital anesthesia or while conscious. Compared with previously reported data from albino rats, pigmented subjects generally showed increased salicylate uptake. Moreover, the data suggested two different, time-dependent clearance mechanisms in conscious animals not observed in anesthetized rats.Daily injections of salicylate did not produce an accumulation of salicylate in serum. Systematically higher levels of salicylate were observed in perilymph compared with cerebrospinal fluid. Behavioral procedures, including water deprivation and conditioned suppression of ongoing drinking levels, had no effect on salicylate levels.

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Hypocalcemic effect of acetylsalicylic acid in rats.

Cited by 9 publications

References 4 publications

Modulation of Radiation Injury in Pregnant Rats by Bone Marrow Transplantation

Modulation of Radiation Injury in Pregnant Rats by Bone Marrow Transplantation

Differential Uptake of Salicylate in Serum, Cerebrospinal Fluid, and Perilymph

Pigmentation, Anesthesia, Behavioral Factors, and Salicylate Uptake

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