The genetic adaptation of Tibetans to high altitude hypoxia likely involves a group of genes in the hypoxic pathway, as suggested by earlier studies. To test the adaptive role of the previously reported candidate gene EP300 (histone acetyltransferase p300), we conducted resequencing of a 108.9 kb gene region of EP300 in 80 unrelated Tibetans. The allele-frequency and haplotype-based neutrality tests detected signals of positive Darwinian selection on EP300 in Tibetans, with a group of variants showing allelic divergence between Tibetans and lowland reference populations, including Han Chinese, Europeans, and Africans. Functional prediction suggested the involvement of multiple EP300 variants in gene expression regulation. More importantly, genetic association tests in 226 Tibetans indicated significant correlation of the adaptive EP300 variants with blood nitric oxide (NO) concentration. Collectively, we propose that EP300 harbors adaptive variants in Tibetans, which might contribute to high-altitude adaptation through regulating NO production.
“electric control and PLC” is a specified course with much practicability. Its teaching content comes from producing practice. As the application field is extending, the content of courseware becomes more and more abundant. Therefore, to emphasize practical teaching and to reform the course generally has been imperative under the situation.in this paper, a new system of PLC Three-dimensional Teaching was adopt. The experience and methods in terms of making proper teaching objectives, optimizing teaching content, improving teaching manner, stressing practical teaching and training practical ability, were proposed in this paper, through experimental teaching, course design, production practice and integrated training, the students’ engineering practice ability and creative ability have been improved dramatically. this did a significative exploration on improving teaching level and culturing engineering technology persons with high diathesis.
In order to perfectly make the bridge function, structural style, architectural art modeling with the surrounding environment, this paper, based on the design of landscape five-span arch footbridge, studies the span arrangement, structural style, building materials, railing shape, ornament style and color, and lamplight illumination of the bridge considering the factors such as hydrology, geology, surrounding environment (e.g. buildings and park), traffic flow and entire urban planning. To reduce the stress of main arch and the horizontal thrust of substructure, the new structure of T-frame with sloped plate was put forward to bear the deck loads with the assistance of main plate arch. The thin concrete walls were cast on the top sides of the main plate arch, which were decorated by fine stone with the modern decoration construction technology. The white marble railings present lively morphology with carved lotus and pomegranate on the column cap, and many kinds of flowers on the panels. The spotlights make dramatic night sense for the bridge. Therefore, the landscape footbridge in the classical arch graceful shape was constructed by the modern building material and the optimized reinforced concrete structure, which presents the unity and coordination of structural design and artistic expression.
Combined with the design of a bridge with prestressed concrete continuous box-girder, and in accordance with the Chinese guidelines of seismic design for highway bridge, the numerical models with and without considering the pile-soil action were built using Midas Civil software. The response spectrum method was used to analyze the seismic response of the bridge under E1 and E2 seismic actions. The vibration characteristics such as frequency, period and mode as well as the internal forces and displacements of piers are discussed in view of the effect of the pile-soil action.
Combined with the practical design of a prestressed concrete continuous box-girder bridge with changed sections, the effect of side-web slope on the loading properties of this bridge was analyzed. The numerical modes of this bridge were built using the specialist FEM software, 5 side-web slopes were considered by changing the width of box floor. The results show that the changes of side-web slope influence the mid-span deflection of box-girder in a small range under vehicle load, but affect obviously on the transversal loading properties such as crack width and flexural resistance of the box roof. Based on this, the suitable side-web slope is selected. It may be referenced by the similar design of this kind of bridges.
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