No abstract

The versatility of superparamagnetic iron-oxide nanoparticles (SPIONs) have been extensively investigated, especially for their applications in therapeutics and diagnostics. Considering their intriguing feature of contrasting agent, in terms of medical applications, it is still in its infancy. Various physicochemical parameters like magnetism, crystallinity, and optical parameters contribute to their better contrasting agent. In this study, SPIONs were synthesized with different concentrations of precursor iron molecular solution in the presence of magnetic field and the optimum concentration of precursor iron molecular solution was determined as 0.133%. SPIONs obtained at optimum concentration were further analyzed by both microscopic and spectroscopic analysis. The difference occurred in the elemental nature of SPIONs as they were synthesized in the magnetic field out of precursor iron molecular solution was analyzed with a specific reference to NMR spectroscopy. SPIONs as contrasting agent against X-ray imaging was also investigated in quail's egg.

Abstract:In this study, spherical silver nanoparticle (AgNP) was produced by sustainable chemical method i.e. glucose reduction method and it was utilized to analyse the bactericidal effect against the pathogens of clinical importance -E. coli (ATCC 10536) and Enterobacter sp., KL46 by membrane destabilization and protein leakage analyses. Minimum inhibitory/bactericidal and antibiogram analyses reported that 20ng/ml was enough to inhibit/kill bacterial cells. Even 20ng/ml concentration of AgNPs was found to destabilize membrane and lead to protein leakage from bacterial cells.

In this study, curcumin (CUR) was encapsulated into chitosan (CS) and carboxymethyl cellulose (CMC) microparticles using sodium tripolyphosphate (TPP) as chelator. Here, different concentrations (0.1%, 0.3% and 0.5%) of sodium tripolyphosphate (TPP) were utilised to synthesise microparticles. Microparticles were characterized by Fourier Transform Infra-Red Microscopy (FTIR) and Scanning Electron Microscope (SEM). All the CUR encapsulated microparticles were analysed for their drug encapsulation efficiency and the drug release kinetics. Microparticles were studied for the invitro controlled drug release against Pseudomonas aeruginosa.