Cold storage and cryopreservation of PLTs led to morphologic and metabolic changes. However, storage under these conditions appears to maintain or even enhance certain aspects of in vitro PLT function.

There are distinct differences between cryopreserved and liquid-stored PLTs. Cryopreserved PLTs also have an enhanced hemostatic activity. Knowledge of these in vitro differences will be essential to understanding the outcomes of a clinical trial comparing cryopreserved PLTs and liquid PLTs stored for various durations.

encompasses an array of noncovalent interactions that can yield highly complex and ordered structures. As a result of their wide availability and negligible toxicity cyclodextrins (CDs) are one of the most widely used hosts in the fi eld of inclusion chemistry. Usually composed of six to eight D -glucose units, CDs are capable of forming inclusion complexes with various guest moieties and polymeric chains. This capability is attributed to their ether-like oxygen and their hydrocarbon frame creating a hydrophobic cavity wherein appropriately sized molecules and macromolecules can be immobilized via tight, yet reversible associations. Using CD-based inclusion chemistry as a platform, a diverse range of polymeric networks with applications in the life sciences, biotechnology, and materials science can be achieved. This review highlights the versatility of CDbased inclusion chemistry, and how specifi city and control can be imparted when designing higher-order structures, such as those found in biological systems. A particularly interesting group of polymeric structures that is achievable via CD-based inclusion chemistry is that of CD-based The application of cyclodextrin (CD)-based host-guest interactions towards the fabrication of functional supramolecular assemblies and hydrogels is of particular interest in the fi eld of biomedicine. However, as of late they have found new applications as advanced functional materials (e.g., actuators and self-healing materials), which have renewed interest across a wide range of fi elds. Advanced supramolecular materials synthesized using this noncovalent interaction, exhibit specifi city and reversibility, which can be used to impart reversible cross-linking, specifi c binding sites, and functionality. In this review, various functional CD-based supramolecular assemblies and hydrogels will be outlined with the focus on recent advances. In addition, an outlook will be provided on the direction of this rapidly developing fi eld.

Ultrathin metal–organic framework (MOF) nanosheets show great potential in various separation applications. In this study, MOF nanosheets are incorporated as a gutter layer in high-performance, flexible thin-film composite membranes (TFCMs) for CO2 separation. Ultrathin MOF nanosheets (∼3–4 nm) were prepared via a surfactant-assisted method and subsequently coated onto a flexible porous support by vacuum filtration. This produced an ultrathin (∼25 nm), extremely flat MOF layer, which serves as a highly permeable gutter with reduced gas resistance when compared with conventional polydimethylsiloxane gutter layers. Subsequent spin-coating of the ultrathin MOF gutter layer with a polymeric selective layer (Polyactive) afforded a TFCM exhibiting the best CO2 separation performance yet reported for a flexible composite membrane (CO2 permeance of ∼2100 GPU with a CO2/N2 ideal selectivity of ∼30). Several unique MOF nanosheets were examined as gutter layers, each differing with regard to structure and thickness (∼10 and ∼80 nm), with results indicating that flexibility in the ultrathin MOF layer is critical for optimized membrane performance. The inclusion of ultrathin MOF nanosheets into next-generation TFCMs has the potential for major improvements in gas separation performance over current composite membrane designs.

A novel tertiary amine catalyst (TAC) and trithiocarbonate (TTC) synergistic photo-induced controlled radical polymerization of methacrylates in the absence of conventional photoinitiators, metal-catalysts, or dye sensitizers, has been realized under mild UV irradiation (λ max ≈ 365 nm), yielding polymethacrylates with low molecular weight distributions and excellent end-group fidelity (> 95%).