The OSCC-OSMF was found to be a clinicopathologically distinct entity with a better grade of tumor differentiation, less incidence of nodal metastases, and early detection (early clinical TNM stage) compared to OSCC. All these factors probably contribute to a better prognosis and increased 3-year disease-free survival in OSCC-OSMF patients.
Objective: Interaction between reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a crucial determinant in the etiology of oral squamous cell carcinoma (OSCC), and antioxidants protect against cellular and molecular damage caused by these. This study aims to evaluate ROS and RNS, together with the total antioxidant capacity (TAC), in serum and tissues of OSCC patients. Method: Total nitric oxide (TNO), malondialdehyde (MDA), and TAC were evaluated using a UV visible spectrophotometer in the serum of 30 controls, 30 precancer and 30 OSCC patients and in tissues of 10 controls and 30 OSCC patients. Results: MDA and TNO were significantly elevated with concomitant depletion of TAC in serum and tissues of OSCC patients when compared to controls. A significant positive correlation (p = 0.01), at different levels between TNO and MDA in OSCC patients, was found, which increased with the grade of OSCC. Conclusion: An increase in the levels of TNO, NO-mediated lipid peroxidation, resulting in an increase in MDA levels, the positive TNO-MDA correlation with a deranged antioxidant defense system as demonstrated by significantly low levels of TAC; when all these facts are taken together, we can conjecture that oxidative DNA damage, a vital phenomenon for carcinogenesis, occurs due to the interplay of ROS, RNS and TAC.
The results suggest that tumor angiogenesis may play an important role in locally invasive aggressive biologic behavior of ameloblastoma and keratocystic odontogenic tumor. The angiogenesis could be a potent target for developing antiangiogenic therapeutic strategies, particularly in recurrent cases of odontogenic tumors.
Cysticercosis is the result of infestation with the larval stage of the tapeworm (Taenia solium). Cysticercosis is a potentially fatal parasitic disease when involving the central nervous system (neurocysticercosis). This article reports two cases of oral cysticercosis and reviews 133 reported cases in English language literature. The prevalence of oral cysticercosis was 3.5% out of 769 cases of cysticercosis. Tongue is the most commonly affected site followed by buccal mucosa and lower lip. Most oral lesions appeared as asymptomatic submucosal nodules. Multiple oral involvements have been reported in few cases. Both genders were nearly equally affected. Fine needle aspiration cytology has also been used for preoperative diagnosis. The definitive diagnosis was done histopathologically. Simple surgical excision was sufficient to ensure complete removal. It is important to carry out a detailed medical evaluation in every case, in order to exclude the presence of the parasite at other sites. Medical treatment with antihelminthics drugs such as Praziquantel and Albendazole used for multiple involvement and neurocysticercosis.
Background:
The clinicopathological distinctness of oral squamous cell carcinoma arising in the background of oral submucous fibrosis (OSCC-OSF) is well known; however, the molecular distinctness of this unique OSCC-OSF has not been investigated to date. With this in mind, we compared the expression of
Ki67
,
CD105
, and
α-SMA
between OSCC-OSF and oral squamous cell carcinoma (OSCC).
Methods:
Formalin-fixed paraffin-embedded tissues of 105 OSCC-OSF and 112 OSCC cases were subjected to immunohistochemistry for evaluation of
Ki67
,
CD105
, and
α-SMA
expression.
Results:
Ki67
(labeling index)
LI
,
MVD
and
α-SMA
expression were significantly higher in OSCC compared to OSCC-OSF.
Ki67 LI
and
MVD
was significantly higher in OSCC compared to OSCC-OSF in parameters such as well-differentiated, early TNM stage, non-metastatic, and more than 3-year survival. α-SMA expression was significantly higher in OSCC compared to OSCC-OSF in parameters such as moderate differentiation, metastatic lesions, and survival less than 3 years.
Ki67 LI
,
MVD
and
α-SMA
showed significant positive correlation with each other in OSCC and OSCC-OSF.
Conclusion:
Proliferation, neoangiogenesis and myofibroblast differentiation were significantly higher in the OSCC group compared to the OSCC-OSF group. This suggests the biological distinctness of OSCC-OSF, which could help the future development of targeted therapies.
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