The OSCC-OSMF was found to be a clinicopathologically distinct entity with a better grade of tumor differentiation, less incidence of nodal metastases, and early detection (early clinical TNM stage) compared to OSCC. All these factors probably contribute to a better prognosis and increased 3-year disease-free survival in OSCC-OSMF patients.
The result suggests that CD105 (endoglin) is strongly expressed in microvessels of KCOT compared with that in Dentigerous cyst and Normal oral mucosa. Thus, it suggests that angiogenesis may be associated with locally aggressive biological behavior of KCOT. These findings further stress on the hypothesis that the stroma of KCOT could be regarded not just as a structural support of the cyst wall, but as playing a part in the neoplastic behavior of cyst.
In this article we report a case of rare composite odontogenic tumor, having features similar to adenoid ameloblastoma with dentinoid described previously. The histological features are similar to both ameloblastoma and AOT and show evidence of induction in the form of dentinoid. The patient was a 35 years old female. The lesion was located on right side of the mandible in premolar‐molar area. Radiograph revealed unilocular radiolucency with foci of radio‐opacities. On gross examination the tumor was cystic at places. The histopathological features consists of two patterns, one resembling AOT and other plexiform ameloblastoma. The formation of dentinoid like material was observed in association with odontogenic epithelium. Apart from this the presence of ghost cells was a unique histopathological feature.
This article also reviews the various cases reported in literature and provides an insight into the nature of composite odontogenic tumor. To date only 12 cases of this uncommon composite odontogenic tumor are reported in the literature.
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