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Multidrug-Resistant (MDR) cancer may be treated using combinations of encapsulated cytotoxic drugs or chemo sensitizers. To optimize for the effectiveness of this combinational approach poly (lactic-o-glycolic acid) nanoparticle formulations capable of delivering a cytotoxic drug or chemo sensitizers, Ursolic Acid (UA) and Caffeine (Caf) combination were prepared. The system can be used for targeting, controlled drug delivery and also imaging of cancer cells. The prepared nanoparticles were characterized using DLS, TEM, XRD and FTIR studies. The drug loaded nanoparticles exhibited significant antitumor effects and high tumour targeting ability towards HT29 human colon cancer cells. The aforementioned results indicated that the drug loaded nanoparticle prepared in the study had a specific interaction with colon cells. Therefore, the prepared nanoparticle may be used as a potential drug delivery system for the targeted delivery to colon cancers.

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Small peptides from snake venom are studied as exceedingly selective, specific, effective and harmless therapeutics. This review article critically analyzes with numerous examples for the use of snake venom components as a potential therapeutic tool against various illnesses. The active components from numerous venoms are isolated, purified and used in assays to identify the specific therapeutic components that were categorized based on their biological goal and mechanism of action. This has paved the ways to use peptides from venom as therapeutic drugs. Peptide toxins are usually active orally, via subcutaneous, intramuscular or intravenous administrations. These peptides are targeting a wide range of membrane-bound protein channels and receptors. Peptides are recovered from the venom of diverse animals and most of these possess the possible prospects of safety after isolation and purification and venom-obtained peptides that can become practical drugs effectively, in future.

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