Enzyme inhibiting activity X 0220Novel δ 2 -Isoxazolines as Group II Phospholipase A 2 Inhibitors. -Novel imidazolyl δ 2 -isoxazoline libraries are constructed via key intermediate (I) through 1,3-dipolar cycloaddition reaction with dipolarophiles like mono substituted alkenes. The crystal structure of imidazolylcarbaldehyde oxime (I) is determined by X-ray diffraction. The novel δ 2 -isoxazolines are evaluated for their phopholipase A2 enzyme inhibitory activity against snake venom source and the structure-activity relationship of this type of molecules is discussed. The new compounds exert significant PLA2 enzyme inhibitory activity against group II PLA2. Compounds (II) show antiinflammatory in vivo activity, comparable to that of ursolic acid. -(BASAPPA; KUMAR, M. S.; SWAMY, S. N.; MAHENDRA, M.; PRASAD, J. S.; VISWANATH, B. S.; RANGAPPA*, K. S.; Bioorg. Med. Chem. Lett. 14 (2004) 14, 3679-3681; Dep. Stud. Chem., Univ. Mysore, Manasagangotri, Mysore 570 006, India; Eng.) -H. Hoennerscheid 47-217
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