Snake Venom-Derived Peptides as Prospective Pharmacological Tools: Recent Trends

Rajan, Sheeja S; Subramanian, Perumal; Merlin, Jon

doi:10.22159/ijcpr.2022v14i1.44106

Cited by 3 publications

(1 citation statement)

References 166 publications

(186 reference statements)

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“…Management of poisoning is one of the biggest challenges faced by health care professionals globally [3]. There are reports of the treatment of numerous diseases through the venom of some poisoned species e. g., lionfish spine poison extract [4] and snake venoms [5][6][7]. Scorpions venom also finds applications in the diagnosis of various diseases, including tetanus, epilepsy, chronic and acute convulsion [8].…”

Section: Introductionmentioning

confidence: 99%

Potential of Scorpion Venom for the Treatment of Various Diseases

JAVED¹,

Hussain²,

KHAN³

et al. 2022

Int J Chem Res

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The venom of various scorpion species finds significant therapeutic applications. It is rich in neurotoxins, enzymes, enzyme inhibitors, histamine, lipids and different salts from which peptides demonstrate a great potential against a variety of diseases. Many biological functions e. g., bradykinin potentiating, hemolytic, anti-cancer, anti-microbial, and anti-inflammatory potential are being regulated by non-disulfide-bonded peptides. Therefore, it is motivating to use these properties for the treatment of cancer, cardiovascular diseases, diabetes, AIDS, apoplexy, influenza H5N1, paralysis, epilepsy, malaria, measles, severe combined immunodeficiency, fever blisters and diabetes. Scorpion venom has shown the presence of 100,000 bioactive compounds but only 1 % of these have been purified, isolated and characterized by HPLC and mass spectroscopy etc. For the production of high-quality antivenom with specific antibodies, gentler electrical stimulation is a better method as compared to manual production. Recombinant DNA technology has facilitated the identification of new components. Some important medicinal compounds isolated from scorpion venom include HsTX1 (from Heterometrus spinnifer), mucroporin-M1 (from Lychas mucronatus), chlorotoxin and charybdotoxin (from Leiurus quinquestriatus hebraeus). B. leptochelys venom has shown the presence of at least 148 components. Six novel long-chain peptides were isolated from the scorpion Buthus martensi Karsch venom. Crude venom of L. Abdullah bayrami displays a proliferative effect on MCF-7 cells and also shows antimicrobial potential. A new toxin derived from the venom of Liocheles waigiensis [U1-liotoxin-Lw1a (U1-LITX-Lw1a)] displays significant insecticidal action. The computational studies may play an important role while developing ion channel drugs from venom peptides.

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Section: Introductionmentioning

confidence: 99%

Potential of Scorpion Venom for the Treatment of Various Diseases

JAVED¹,

Hussain²,

KHAN³

et al. 2022

Int J Chem Res

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Unlocking nature's arsenal: Nanotechnology for targeted delivery of venom toxins in cancer therapy

Chary,

Shaikh,

Rajana

et al. 2024

Biomaterials Advances

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Investigating the Binding Efficacy of Snake Venom Proteins as GLP-1 Analogs for Diabetes mellitus Management: An In silico Study

Gunta,

Kandula,

Gorti

et al. 2023

Orient. J. Chem

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Objective: Diabetes mellitus (DM) is a metabolic condition defined by hyperglycemia driven by insulin deficiency or decreased insulin activity. GLP-1, a gut enzyme, stimulates insulin production and reduces hepatic glucose synthesis to regulate diabetes. GLP-1 agonists enhance insulin sensitivity and decrease blood glucose to relieve symptoms of DM. These medications represent a novel paradigm to manage diabetes as they improve glycaemic control in type 2 diabetic patients. Snake venom proteins have been investigated as a potential medicinal strategy for diabetes treatment. These proteins contain a multitude of bioactive constituents, such as insulinotropic cytotoxins, which have been found to influence insulin secretion and glucose homeostasis. Methods: In the present study, the snake venom proteins long neurotoxin 1 Cytotoxin 7, Cytotoxin 2a, and Cytotoxin 10 were modeled and their therapeutic efficacy as GLP-1 analogs was determined by employing molecular docking techniques. The binding of snake venom protein towards GLP-1 receptors was compared against the positive controls (Exenatide, Liraglutide, Semaglutide, and Lixisenatide). Results: The results demonstrated that the cytotoxins (Cytotoxin 2a, Cytotoxin 7, and Cytotoxin 10) exhibited comparable binding with the positive controls and majorly interacted with the hydrophobic amino acids in the binding pocket of the GLP-1 receptor. The modeled snake venom toxins demonstrated beneficial physicochemical properties and advocated them to be a novel contender for the development of GLP-1 analogs. Conclusion: Despite its beneficial outcomes, the utilization of snake venom proteins as a therapeutic agent for diabetes is still in its initial stages, and additional research is required to assess their effectiveness and safety in patients.

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Snake Venom-Derived Peptides as Prospective Pharmacological Tools: Recent Trends

Cited by 3 publications

References 166 publications

Potential of Scorpion Venom for the Treatment of Various Diseases

Potential of Scorpion Venom for the Treatment of Various Diseases

Unlocking nature's arsenal: Nanotechnology for targeted delivery of venom toxins in cancer therapy

Investigating the Binding Efficacy of Snake Venom Proteins as GLP-1 Analogs for Diabetes mellitus Management: An In silico Study

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