The effect of a single oral dose of omeprazole (90 mg) on gastric emptying was assessed with a dual isotope scintigraphic technique in eight patients with a history of duodenal ulcer disease. Omeprazole had no significant effect on solid or liquid gastric emptying. The bioavailability (AUC0‐2 h) of omeprazole in all patients was greater than that required for total suppression of acid secretion. No adverse clinical or laboratory effects were observed.

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Summary. This study investigated the inhibition by colostrum of the uptake of tritiiited thymidine by bolh autologous and heterologous peripheral blood mononucicitr cells (PBMC) stimulated with the mitogens phytohaemuggluiinin (PHA), pokeweed mitogen (PWM) or Concanavalin A (Con A). This inhibition was not the result of :in .ilteration in Ihe dose response or kinetics of mitogenesis by the colostrum. The inhibitory faclor in the colostrum was neither dialysable nor lymphocytotoxic. Lymphocyies which were briefly pre-treated with colostrum, then washed and cultured, also incorporated much less labelled thymidine than control cells. The inhibitory factor was not adsorbed from colostrum by mononuclear cells. We conclude that colostrum contains a cytostatic factor which inhibits mitogenesis in PBMC.

Immunoglobulin allotype and serum antigliadin antibodies in coeliac disease

No abstract