The effect of omeprazole on gastric emptying in patients with duodenal ulcer disease.

Horowitz, Michael; Hetzel, DJ; Buckle, PJ; Chatterton, B. E.; Dj, Shearman

doi:10.1111/j.1365-2125.1984.tb02544.x

Cited by 41 publications

(19 citation statements)

References 13 publications

(23 reference statements)

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“…Thus, studies about the potential impact of PPIs on gastric emptying have clinical relevance. To date, the variable effects of omeprazole [5, 6] and lansoprazole [7, 8] on gastric motor function have been reported. It is considered that PPI-induced acid suppression with or without hypergastrinemia indirectly affects gastric motility [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Dual Effects of Rabeprazole on Solid-Phase Gastric Emptying Assessed by the <sup>13</sup>C-Octanoate Breath Test

Anjiki¹,

Sanaka²,

Kawakami³

2005

Digestion

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Background/Aims: Knowledge is limited regarding the effects of rabeprazole on gastric emptying. This randomized, open, crossover study was undertaken to investigate the effects. Methods: In 24 healthy volunteers (13 men and 11 women, aged 22–53 years), solid emptying was assessed twice using the ¹³C-octanoate breath test. On one occasion, the subjects received 20 mg rabeprazole for the preceding 2 days and 1 h before the test. On another occasion, they underwent no pretreatment. The time course of cumulative recovery of ¹³CO₂ in breath was fitted to z(t) = m(1 – e^–kt)^β^–1, and regression constants of k and β were determined. The half ¹³CO₂ excretion time (t_½b) and the time of maximal excretion (t_max) were calculated. Under the crossover protocol, k and β can describe the emptying features more precisely; a larger (smaller) β indicates a slower (faster) emptying in the early phase, and a larger (smaller) k indicates a faster (slower) emptying in the later phase. Between the two occasions, k, β, t_½b, and t_max were compared. Results: Rabeprazole significantly decreased k and β, significantly prolonged t_½b, but t_max remained unchanged. Conclusion: Rabeprazole has dual effects on solid emptying: an initial acceleration with a subsequent deceleration, resulting in an overall delay.

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Section: Introductionmentioning

confidence: 99%

Dual Effects of Rabeprazole on Solid-Phase Gastric Emptying Assessed by the <sup>13</sup>C-Octanoate Breath Test

Anjiki¹,

Sanaka²,

Kawakami³

2005

Digestion

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“…22 Yet, these studies are far from explaining the effects of PPIs on pylorus activities. Relexant or inhibitory effects of PPIs at high doses were demonstrated on vascular precontracted smooth muscle, gallbladder, prostate, corpus cavernosum, myometrium, and lower esophageal sphincter.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Effects of Rabeprazole on Human Pylorus Tone

Yaşar

Polat

Duman

et al. 2015

J Neurogastroenterol Motil

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Background/Aims It has been reported that proton pump inhibitors induce relaxation in different types of smooth muscles. The aim of this study is to investigate in vitro effects of proton pump inhibitors on human pylorus muscle. Methods Pyloric sphincters were studied in 10 patients who were operated for stomach cancer. In isolated organ bath, control and response to rabeprazole were recorded following contraction with carbachol. During the treatment experiment, while distilled water was applied during the control experiment in every 5 minutes, rabeprazole was administered in every 5 minutes at doses of 10 −6 , 10 −5 , 10 −4 , and 10 −3 M respectively. Contraction frequencies, maximum contraction values and muscle tones were measured. Results The contraction frequencies in the control group were greater than the rabeprazole group in the second, third and fourth intervals while the maximum contraction values in the rabeprazole group were lower in the fourth interval. Even though muscles tones were not different in both groups during all intervals, it was remarkable that the muscle tone was significantly decreased in the rabeprazole group during the fourth interval compared to the first and second intervals. Conclusions In the present study, high doses of rabeprazole reduced contraction frequencies, maximum contraction values, and muscle tone of human pylorus.

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“…However, when the stomach was alkalinized by intragastric infusion of 7%sodium bicarbonate, an increase of gastric motor activity was found in only 2/7 subjects. In addition, since it has been reported that upper gastrointestinal motility is not increased by omeprazole, a proton-pump inhibitor which more potently inhibits gastric acid secretion than H2-receptor antagonists (28,29), the rise in intragastric pH does not appear to be the only cause of the increase in gastrointestinal motility.…”

Section: Les Pressure Associated With Gastric Phasic Motor Activity Imentioning

confidence: 99%

Effect of H2-Receptor Antagonists Cimetidine and Famotidine on Interdigestive Gastric Motor Activity and Lower Esophageal Sphincter Pressure in Progressive Systemic Sclerosis.

1994

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The effect of the H2-receptor antagonists cimetidine and famotidine on interdigestive gastric motor activity and lower esophageal sphincter pressure was assessed in 41 patients with uncomplicated progressive systemic sclerosis. There was no significant change in gastric phasic motor activity after the intravenous administration of cimetidine (n=6), famotidine (n=13), and physiological saline (n=15), or the intragastric infusion of 7%sodium bicarbonate (n=7). The lower esophageal sphincter pressure was increased significantly by both cimetidine and famotidine, but only famotidine caused a significant pressure rise in patients without an increase of gastric motility.Cimetidine and physiological saline produced a similar pattern of change in the esophageal sphincter pressure, as did famotidine and sodium bicarbonate. These findings suggest that the inhibition of acetylcholinesterase activity and gastric acid secretion may be involved in the respective mechanismsof action of cimetidine and famotidine. (Internal Medicine 33: 407-412, 1994)

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The effect of omeprazole on gastric emptying in patients with duodenal ulcer disease.

Cited by 41 publications

References 13 publications

Dual Effects of Rabeprazole on Solid-Phase Gastric Emptying Assessed by the <sup>13</sup>C-Octanoate Breath Test

Dual Effects of Rabeprazole on Solid-Phase Gastric Emptying Assessed by the <sup>13</sup>C-Octanoate Breath Test

In Vitro Effects of Rabeprazole on Human Pylorus Tone

Effect of H2-Receptor Antagonists Cimetidine and Famotidine on Interdigestive Gastric Motor Activity and Lower Esophageal Sphincter Pressure in Progressive Systemic Sclerosis.

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