Inhibition by Colostrum of the Responses of Peripheral Blood Mononuclear Cells to Mitogens

Drew, PA; Om, Petrucco; Dj, Shearman

doi:10.1038/icb.1983.42

Cited by 7 publications

(3 citation statements)

References 1 publication

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“…In our studies on the lymphocyte response to the stimulation of phenotype-specific mitogens, it is noteworthy that these two fractions did not exert any significant effects in vivo, but their effects on the proliferative response of T lymphocytes but not B lymphocytes in vitro were highly suppressive and dose-dependent (Tables 4 and 5). Inhibitory or cytostatic factors that can suppress both T and B lymphocyte responses to mitogenic stimulation have been known for many years to be present in human colostrum (Drew et al 1983). Whether similar factors were also present in these two fractions remains to be determined.…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory activities of whey fractions in efferent prefemoral lymph of sheep

Wong

Regester

Francis

et al. 1996

Journal of Dairy Research

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SummaryStudies on the immunomodulatory activities of ruminant milk and colostral whey fractions were undertaken. By comparing with boiled colostral whey in a preliminary experiment, a putative heat-labile immunostimulatory factor for antibody responses was found to be present in ovine colostral whey. Studies were then undertaken in sheep in which the efferent prefemoral lymphatic ducts were cannulated bilaterally, and immune responses in the node were measured following subcutaneous injection in the flank fold of whey protein preparations of various purities. A significant sustained decline of efferent lymphocyte output was observed following injection with autologous crude milk whey or colostral whey preparations, but no changes were observed in interferon-gamma levels in lymph plasma. Two bovine milk whey fractions (lactoperoxidase and lactoferrin) of high purity were compared in bilaterally cannulated sheep. A transient decline over the first 6 h was seen in the efferent lymphocyte output and lymph flow rate after injection of both fractions. A significant difference was seen between the two fractions in interferongamma levels in lymph at 6 h after injection. However, no significant changes in the proportion of the various efferent lymphocyte phenotypes were seen following either treatment. Whereas both fractions showed a significant inhibitory effect in a dose-dependent manner on the proliferative response of T lymphocytes, but not B lymphocytes, to mitogenic stimulation in vitro, no similar changes were seen following in vivo stimulation with these two fractions.

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Section: Resultsmentioning

confidence: 99%

Immunomodulatory activities of whey fractions in efferent prefemoral lymph of sheep

Wong

Regester

Francis

et al. 1996

Journal of Dairy Research

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“…There was a notable lack of differences in vaccine response between animals grouped on the basis of their combined birth/rearing environment. Although maternal influences, through high colostral antibody and non‐specific colostral immunosuppressive factors, have been found to influence vaccines response in young ruminants (H usband and L ascelles 1975; D rew et al 1983), maternal environmental and genetic factors have not been examined. The data presented here did not allow maternal effects to be examined in detail in the case of the footrot vaccines, but in the case of clostridial vaccination, the data was sufficient to make preliminary comments on the relative importance of these factors.…”

Section: Discussionmentioning

confidence: 99%

Disease resistance in Merino sheep. V. Genetic heterogeneity in response to vaccination with Dichelobacter nodosus and clostridial antigens

Raadsma

Attard

Nicholas

et al. 1996

J Animal Breeding Genetics

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Summary Genetic aspects of antibody responses in two commercial, multivalent vaccines were examined in 2 974 Merino sheep, representing the progeny from 129 sires in four major bloodlines. All lambs were vaccinated twice, between 2 and 4 months of age, with a clostridial vaccine containing antigens against five clostridial species. Approximately half (1 239) the progeny from all sires were also vaccinated at 16 months of age, with a Dichelobacter nodosus vaccine containing whole‐cell antigens from all nine major serogroups (A–I). ELISA antibody titres to Clostridium tetani and Clostridium chauvoei were measured 2 weeks after booster vaccination. K‐agglutinating antibody titres, against all serogroups of D. nodosus, were measured on three occasions–following primary vaccination (V1), 3 and 8 weeks following booster vaccination (V2). Mean antibody titre on all three occasions (MEAN POST‐VAC), and changes in antibody titre between V1 and V2, and after V2, were analysed as additional antibody traits for D. nodosus. For both clostridial and D. nodosus antibody traits, year of birth and flock were major fixed effects. Sex of the lamb was not important in the case of clostridial antibody titres, but ewe hoggets had consistently higher D. nodosus antibody titres compared to those for ram hoggets from the same cohort. Based on restricted maximum likelihood (reml) analyses, heritability estimates for C. tetani and C. chauvoei were 0.12 (± 0.04) and 0.24 (± 0.07). Preliminary estimates for maternal effects showed additive maternal genetic variance for C. tetani and C. chauvoei (0.09 ± 0.05 and 0.17 ± 0.07). Maternal environmental effects appeared negligible. Heritability estimates of D. nodosus antibody titre for all nine serogroups ranged from 0.22 to 0.66 following V1, and were approximately 40% higher than those following V2 (range 0.17–0.44), which in turn were approximately 50% higher than estimates for persistence of titre (range 0.08–0.32). Genetic correlations for antibody titre at consecutive samplings were high, and the heritability estimates for MEAN POST‐VAC titre for each serogroup of D. nodosus were: A (0.51), B (0.58), C (0.41), D (0.24), E (0.34), F (0.33), G (0.26), H (0.34), and I (0.35). Genetic correlations for antibody titres among the nine D. nodosus serogroups ranged from moderately negative (–0.40) to strongly positive (0.87). Similarly, genetic correlations between clostridial and D. nodosus antibody titres ranged from –0.08 to 4–0.41. C. tetani antibody titre showed a genetic correlation of +0.50 with C. chauvoei titre. It was concluded that significant additive genetic variation exists in Merino sheep for vaccine response to commercial vaccines. However, there was no strong evidence for common genetic control of immune response to different antigens. Zusammenfassung Krankheitsresistenz bei Merinoshafen. V. Genetische Heterogenität der Reaktion auf Vakzine mit Dichelobacter nodosus und Klostidienantigene Genetische Aspekte de Antikörperreaktion auf zwei komerzielle multivalente Vakzinen wurden an 2...

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“…This is in agreement with the findings of Diaz-Jouanen and Williams (35) and Ogra and Ogra (36) on term milk. This phenomenon could be explained by the presence of a soluble inhibitory factor and/or by a T-cell suppressor activity found in colostrum (37,38). One of the concerns in providing breast milk leukocytes to an immunologically compromised premature infant would be the potential risk of graft-versus-host reaction seen in rats during suckling (39); however, the impaired activity of human colostral lymphocytes may prevent the development of this disease in the newborn infant.…”

Section: Nbt Reductionmentioning

confidence: 99%

Functional Capacity of Colostral Leukocytes from Women Delivering Prematurely

Schlesinger,

Muñoz,

Arevalo

et al. 1989

J. pediatr. gastroenterol. nutr.

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The phagocytic, bactericidal, and metabolic activity of colostral leukocytes from mothers delivering preterm infants was compared with that of colostral leukocytes from mothers of term infants. In addition, the proliferative capacity of colostral lymphocytes was compared. Preterm adherent colostral leukocytes had a significantly higher phagocytic index than term colostral adherent leukocytes. Mean ± SEM values were 5.4 ± 0.5 versus 2.7 ± 0.2, respectively (p < 0.001). Bactericidal capacity against Escherichia coli and nitroblue tetrazolium reduction of preterm and term colostral leukocytes were comparable. Lymphocyte proliferative response was equivalent in preterm and term milk. We conclude that colostral leukocytes from preterm mothers are at least as functional in their antimicrobial activity and possibly phagocytose even better than the colostral cells of mothers of term infants.

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Inhibition by Colostrum of the Responses of Peripheral Blood Mononuclear Cells to Mitogens

Cited by 7 publications

References 1 publication

Immunomodulatory activities of whey fractions in efferent prefemoral lymph of sheep

Immunomodulatory activities of whey fractions in efferent prefemoral lymph of sheep

Disease resistance in Merino sheep. V. Genetic heterogeneity in response to vaccination with Dichelobacter nodosus and clostridial antigens

Functional Capacity of Colostral Leukocytes from Women Delivering Prematurely

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