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Background:The predominant phytoestrogen in soy and derived products is the isoflavone Genistein. Genistein has antioxidant properties. Morphine is a main psychoactive chemical in opium that can increase the generation of free radicals and therefore it could adversely affects the spermatogenesis.Objective: The main goal was to investigate whether the Genistein could protect morphine adverse effects on sperm cells viability, count, motility, and testis histology and testosterone hormone and nitric oxide in blood serum.Materials and Methods:In this study, various doses of Genistein (0, 1, 2, and 3 mg/kg) and Genistein plus morphine (0, 1, 2, and 3 mg/kg) were administered interaperitoneally to 48 male mice for 30 consequent days. These mice were randomly assigned to 8 groups (n=6) and sperm parameters (sperm cells viability, count, motility and morphology), testis weight and histology, testosterone hormone (ELISA method), FSH and LH hormones (immunoradiometry) and serum nitric oxide (griess assay) were analyzed and compared.Results:The results indicated that morphine administration significantly decreased testosterone (0.03 ng/mg) LH and FSH level, histological parameters, count, viability (55.3%), morphology and motility of sperm cells (1%), testis weight (0.08 gr) and increase nitric oxide compared to saline group (p=0.00). However, administration of Genistein and Genistein plus morphine significantly boosted motility, morphology, count, viability of sperm cells, seminiferous tubules diameter, germinal thickness, testosterone, LH and FSH while decrease nitric oxide level in all groups compared to morphine group (p<0.025).Conclusion:It seems that Genistein administration could increase the quality of spermatozoa and prevent morphine- induced adverse effects on sperm parameters.

Aminolevulinic acid (ALA) is a charged, hydrophilic molecule that penetrates poorly through cellular structures. This property has been implicated in the poor clinical response of non-superficial basal cell carcinomas (BCCs) to photodynamic therapy (PDT). Release of ALA hydrochloride from a 20% w/w formulation was found to be incomplete and that approximately 36.8% of the total dose is released during the application period of 4 h. Using scintillation spectroscopy and a precise tissue sectioning protocol, it was demonstrated that depths of penetration of at least 2 mm from the lesion surface had been reached. Using cumulative stratal ALA concentrations, it was found that 10% of the total applied dose permeated into the lesion. In spite of this, comparisons drawn with photodynamic concentrations used in tissue culture work reported elsewhere revealed that estimations of the ALA concentration at 2 mm were sufficient to elicit a possible therapeutic response. Results from this work question the reasons given for poor outcomes of PDT in nodular BCC based solely on depth as a hindering factor.

Pruritic urticarial papules and plaques of pregnancy is a common benign dermatosis of pregnancy that was described in 1979 as an intensely pruritic urticarial cutaneous eruption. This is a well-defined clinical entity that mainly occurs in primigravidas in the third trimester, which resolves spontaneously or with delivery and is usually responsive to topical treatments. The aetiology of PUPPP is obscure. Histology is non-specific, but consistently shows mild lymphohistiocytic perivascular inflammatory infiltrate with a variable number of eosinophils. Immunofluorescent studies are negative. The maternal and fetal prognosis are generally unaffected, and the condition is usually responsive to topical corticosteroids and oral antihistamines.

Background and aims: This study aimed to determine the prevalence of urinary tract infection (UTI) among the pregnant women and the risk factors related to it in Shahrekord, Iran. Methods: In this cross-sectional study, 832 patients were examined during 26 to 30 weeks of pregnancy and their UTIs were studied. The required information was collected by examining the personal pregnancy health records and completion of the data registration forms. All statistical analyses were performed in SPSS software version 23.0 using chi-square and independent t test. Results: According to the results of this study, out of 832 pregnant women, 109 were diagnosed with UTI; hence the prevalence of UTI was recorded to be 13.1% in this study. Moreover, there was a significant relationship between UTI and variables of delivery, severe nausea and vomiting during pregnancy (known as morning sickness), genitourinary disorders, infertility, and blood group. Conclusion: According to the study results, it seems that screening and treatment of UTIs have been done appropriately and in the right time, in health systems of the city of Shahrekord which have led to the reduction of disorders in infants, as well as maternal diseases. Even in the absence of any UTIrelated symptoms, screening tests for UTI are recommended