Effect of Genistein on reproductive parameter and serum nitric oxide levels in morphine-treated mice

Jalili, Cyrus; Ahmadi, Sharareh; Roshankhah, Shiva; Salahshoor, Mohammad Reza

doi:10.29252/ijrm.14.2.95

Cited by 45 publications

(65 citation statements)

References 33 publications

(44 reference statements)

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“…19 Another research also showed a decrease of sperm motility in the group that was intervened with 50 days of stress. 13 Similar results was also found in previous research where sperm viability was significantly reduced in the stress-induced group when compared to control. 17 Another research reported larger abnormal sperm morphology in restricted-diet group when compared to control.…”

Section: Discussionsupporting

confidence: 80%

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The effect of fasting to the quality of spermatozoa in adult male rattus norvegicus

Hafaz

2017

JKKI

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Backround: Oxidative stress contributes in male infertility as a causative idiopathic factor. Fasting is one kind of physical stress that can also cause oxidative stress. Furthermore, oxidative stress would increase ROS concentration. The increase of ROS contributes to infertility and decrease of testis weight. A lot of studies had been conducted on more than 24 hours fasting which leads to reducing sperms quantity, volume, and motility. In the other hand, studies on fasting for less than 24 hours are still limited; therefore study to evaluate the effect of stress caused by fasting for less than 24 hours to the quality of spermatozoa in adult male mice is needed. Objective: To determine the effect of 10 hours and 12 hours fasting to the quality of spermatozoa which included its motility, viability, and morphology in adult male mice. Methods: This study is an experimental research. Three months old male Wistar mice were divided into 3 groups, in which each group contained 10 mice. Group 1 was the control group, group 2 was treated with 10 hours fasting for 14 days, and group 3 was treated with 12 hours fasting for 14 days. After the intervention, their sperm motility, viability, and morphology were observed. Motility and morphology data were analyzed using One-Way ANOVA test, whereas the viability data was analyzed using Kruskal. Results: The sperm's motility, viability, and morphology of the control group were different from the two intervention groups (p < 0,05). Control group had significant difference compared to the group of 10 hours fasting and group of 12 hours fasting (p < 0,05). There was no significant difference between treatment groups (p > 0,05). Conclusion: 10 hours and 12 hours fasting affect the quality of sperm in adult male mice.

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Section: Discussionsupporting

confidence: 80%

“…The observation was done in 200 sperm cells within 10 different fields of view. 12,13 The percentage of sperm morphology was counted by measuring the number of normal sperm divided with a total number of sperm cells being observed and times 100 %.…”

Section: Sperm Morphologymentioning

confidence: 99%

The effect of fasting to the quality of spermatozoa in adult male rattus norvegicus

Hafaz

2017

JKKI

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“…Third to fifth groups (GA administration groups) in which each animal received 5, 10 and 20 mg/kg of GA daily (On days 1-28) for 4 weeks at 10 am, respectively. In sixth to eighth groups (MOR + GA administration groups) each animal was treated with MOR in order to induce reproductive parameters damage at 9.45 am, then they received 5, 10 and 20 mg/kg of GA i.p daily (On days 1-28) at 10 am, respectively (7,13). All experimental treatments were applied i.p.…”

Section: Study Groups and Treatment Of Animalsmentioning

confidence: 99%

“…The tail epididymis was isolated and placed in DMEMF12/FBS 5% culture medium. The testicles were removed from the abdominal cavity and fixed in a 10% formalin solution (7).…”

Section: Study Groups and Treatment Of Animalsmentioning

confidence: 99%

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Effects of gallic acid on rat testopathy following morphine administration: an experimental study

Jalili

Roshankhah

Salahshoor

2020

J Herbmed Pharmacol

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Introduction: Morphine (MOR) as a psychoactive agent in the opium family causes free radicals accumulation which leads to failure in spermatogenesis. Gallic acid (GA), a polyphenolic acid, is found in various plants with antioxidant, anti-fungal, anti-viral, and anti-allergic activities. The purpose of this study was to evaluate the effects of GA against MOR-induced damage to the reproductive parameter of rats. Methods: Sixty-four male Wistar rats (8 weeks, 220-250 g) were categorized into 8 groups by random (n=8/each); normal control and MOR control groups; GA groups (5, 10, 20 mg/kg) and MOR + GA groups (5, 10, 20 mg/kg). Treatments were administered intraperitoneally (i.p), daily for 4 weeks. The sperm parameters, spermatogenesis index (SI), total antioxidant capacity, testosterone level, and seminiferous tube diameter (STD) were assessed. Results: All sperm parameters reduced significantly in the MOR control group than to the normal control group (P < 0.01). All parameters were significantly improved in GA and GA + MOR treatment groups compared to the MOR control group (P < 0.01). Conclusion: MOR caused a detrimental effect on male reproductive parameters. Also, no significant modifications were observed in all doses of GA treatments in comparison with the normal control group. GA compensates the toxic effect of MOR on reproductive parameters. Hence, GA administration is beneficial in MOR users.

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Electrospun drug‐loaded scaffolds for nervous system repair

Kellaway,

Ullrich,

Dziemidowicz

2024

WIREs Nanomed Nanobiotechnol

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Nervous system injuries, encompassing peripheral nerve injury (PNI), spinal cord injury (SCI), and traumatic brain injury (TBI), present significant challenges to patients' wellbeing. Traditional treatment approaches have limitations in addressing the complexity of neural tissue regeneration and require innovative solutions. Among emerging strategies, implantable materials, particularly electrospun drug‐loaded scaffolds, have gained attention for their potential to simultaneously provide structural support and controlled release of therapeutic agents. This review provides a thorough exploration of recent developments in the design and application of electrospun drug‐loaded scaffolds for nervous system repair. The electrospinning process offers precise control over scaffold characteristics, including mechanical properties, biocompatibility, and topography, crucial for creating a conducive environment for neural tissue regeneration. The large surface area of the resulting fibrous networks enhances biomolecule attachment, influencing cellular behaviors such as adhesion, proliferation, and migration. Polymeric electrospun materials demonstrate versatility in accommodating a spectrum of therapeutics, from small molecules to proteins. This enables tailored interventions to accelerate neuroregeneration and mitigate inflammation at the injury site. A critical aspect of this review is the examination of the interplay between structural properties and pharmacological effects, emphasizing the importance of optimizing both aspects for enhanced therapeutic outcomes. Drawing upon the latest advancements in the field, we discuss the promising outcomes of preclinical studies using electrospun drug‐loaded scaffolds for nervous system repair, as well as future perspectives and considerations for their design and implementation.This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Effect of Genistein on reproductive parameter and serum nitric oxide levels in morphine-treated mice

Cited by 45 publications

References 33 publications

The effect of fasting to the quality of spermatozoa in adult male rattus norvegicus

The effect of fasting to the quality of spermatozoa in adult male rattus norvegicus

Effects of gallic acid on rat testopathy following morphine administration: an experimental study

Electrospun drug‐loaded scaffolds for nervous system repair

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