The present study examined the emergence of antisocial lie-telling in very young children. Lie-telling was studied in relation to executive functioning skills and children's abilities to identify both truths and lies. A total of 65 children (M age in months = 31.75, SD = 1.87) participated in a modified temptation resistance paradigm (TRP; designed to elicit spontaneous lies). Executive functioning was measured through an inhibitory control task and a forward search planning task. The Truth/Lie Identification task was administered (Lyon, Carrick, & Quas, 2010) to measure children's abilities to accurately distinguish truths and lies. During the TRP, a total of 89.23% children peeked at the toy when a research assistant left the room, and of those children, 29.31% lied to the research assistant. Significant differences on executive functioning measures were found between lie-tellers and confessors, as well as for the Truth/Lie Identification task. Lie-tellers had higher scores on measures of inhibitory control and forward search planning. Lie-tellers also had higher accuracy on the Truth/Lie Identification task than confessors. This study provides a unique contribution to the literature by examining 2.5-year-old children's emerging lie-telling abilities, a relatively understudied age during which fledgling lie-telling emerges.

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In this study, preschool-aged children's lie-telling behaviour was examined in relation to mental state understanding and executive functioning. Sixty-seven children aged between 25 and 43 months (M = 34.80, SD = 4.39) participated in a temptation resistance paradigm (TRP). Children completed emerging ToM tasks measuring the following mental states: (1) diverse beliefs, (2) diverse desires, and (3) knowledge access. Children also completed measures of inhibitory control and working memory. In total, 63 of the 67 children peeked at the toy during the TRP, and a total of 26 of those children denied their transgression to the research assistant. Inhibitory control and understanding of knowledge access predicted lie-telling behaviour. Results are discussed in relation to a developmental model of children's lie-telling behaviour. Statement of contribution What is already known on this subject? The relationship between lie-telling, executive functioning, and ToM has been established in older children (aged 4 and above). Inhibitory control plays a role in young children's lie-telling (aged 2-4). Children above 3 years of age have some understanding of mental states. What does this study add? Very young children (2-3-year-olds) also possess an understanding of mental states. Mental state understanding is related to 2-3-year-old children's lie-telling behaviours and may be more predictive than inhibitory control. While the results were not significant, this study is the first to look at the unique role of working memory in very young children's lie-telling.

The aim of this review is to provide a contemporary outline of our current understanding of the molecular and genetic events associated with tumorigenesis and the progression of bladder cancer. A comprehensive review of the literature was performed on the molecular alterations associated with transitional cell carcinoma (TCC) of the bladder. Intense research efforts are being made to better identify and characterize various bladder cancers and their true biologic potential. The need to predict which superficial tumors will recur or progress, and which invasive tumors will metastasize has led to a much better understanding of the molecular pathways associated with bladder cancer. The molecular changes that occur in TCC of the bladder are numerous and can be categorized into: (1) chromosomal alterations leading to carcinogenesis, (2) loss of cell cycle regulation accounting for cellular proliferation, and (3) metastasis, guided by events such as angiogenesis. It is becoming apparent that the accumulation of genetic and molecular changes ultimately determines a tumors phenotype and subsequent clinical behavior. At the present time, conventional histopathologic evaluation of bladder cancer (tumor grade and stage) is inadequate to accurately predict the behavior of most bladder tumors. While new laboratory techniques have allowed us to better understand how bladder cancer develops and ultimately progresses, few of these techniques are currently available for use in the clinical setting. The ultimate goal is to develop reliable prognostic markers which will accurately predict not only the expected clinical course of an individual bladder tumor but also the response of that tumor to currently available therapies. More importantly, this information may be employed in the future to dictate altogether new treatments for the prevention and/or stabilization of the early molecular events that lead to the development of bladder cancer.

Although parents frequently instruct children not to lie, children often observe lie‐telling within the family environment. To date, no empirical research has examined children's spontaneous lie‐telling to different lie‐recipients. The current study examined children's spontaneous deceptive behaviour to parents and unfamiliar adults. In Experiment 1 (N = 98), children's (ages 6–9) antisocial lies to a parent or an unfamiliar adult were examined using a modified Temptation Resistance Paradigm. In Experiment 2, (N = 99) children's (ages 6–9) prosocial lies to a parent versus an unfamiliar adult were examined using the Disappointing Gift Paradigm. Results indicate that, across different types of lies, children are more likely to lie to an unfamiliar adult than to a parent. Copyright © 2013 John Wiley & Sons, Ltd.

What's known on the subject? and What does the study add?• Statins have shown broad spectrum anti-cancer properties in laboratory studies. In epidemiological studies, use of statins has been associated with reduced risk of advanced prostate cancer. However, the effects of statins on prostate cancer disease progression following curative treatment have not been extensively studied, and previous studies reported conflicting results.• This study found no clear association between overall statin use and risk of disease progression, as well as lack of a monotone dose-response relationship between the use of statins, whether it was use before or after prostatectomy, and prostate cancer disease progression. Objective• To investigate whether use of HMG-CoA reductase inhibitors ('statins'), which have shown broad spectrum anti-cancer properties in laboratory studies, is associated with a reduced risk of recurrence in patients with prostate cancer who undergo radical prostatectomy. Patients and Methods

Children's (N = 48) and adults' (N = 28) truthful and deceptive statements were compared using a linguistics-based computer software program. Children (4 to 7 years of age) and adults (18 to 25 years of age) participated in a mock courtroom experiment, in which they were asked to recount either a true or fabricated event. Testimonies were then analyzed using Linguistic Inquiry and Word Count Software (LIWC; Pennebaker et al. 2007). This software has been previously used to detect adults' deceptive statements (e.g., Bond and Lee, 2005). To date, no research has used this method on children's narratives, nor has this software been used to compare those narratives to adult counterparts. Markers generated through the LIWC program achieved detection rates of 72.40% for samples of both children's and adults' narratives combined. In contrast, adult laypersons' (N = 48) detection rates, for the same narratives (i.e., both children and adults) were close to chance. More specifically, detection rates were above chance for truth (65.00%) and below chance for lies (45.00%). Thus, the linguistic profile provided through LIWC yielded greater accuracy for evaluating the veracity of children's and adults' narratives compared to adult laypersons' detection accuracy.

In child sexual abuse cases, a central part of the child’s testimony is their description of the abuse episode. However, it is often difficult for children to describe the body mechanics of abuse, and miscommunications are likely to occur. In the present study, we examined questions about the mechanics of abuse in trial transcripts ( N = 63) to identify sources of miscommunication ( N = 130) between attorneys and children (5–12 years old, M age at trial = 9.44, SD = 1.97). We found that both attorneys and children used imprecise language, which led to miscommunication. Specifically, the imprecise use of sexual terminology and the word “touch,” polarity items, broad open-ended questions, anaphora and elliptical questions, and “how” questions led to imprecision in attorneys’ questions. Imprecise attorney questions often elicited underinformative answers from children, including misinterpretations of the grain size (i.e., level of detail) requested. In response to these underinformative answers, attorneys at times asked highly focused and leading questions, which led to further miscommunications. Implications and recommendations for future research on how best to elicit details about the mechanics of abuse from children are discussed.