Fluvastatin's hepatoprotective impact is being investigated in the current study. It is possible that the oxidative stress pathway is implicated in PCM hepatotoxicity. The acute hepatotoxicity of PCM was investigated in this study. Place of study: Rashid Latif Medical College Lahore Materials and Methods: The rabbits were divided into five groups of ten each. The saline group received (the vehicle). Fluvastatin (20 mg/kg), PCM (600 mg/kg), and PCM + 10 mg Fluvastatin (600 mg PCM + 20 mg Fluvastatin) were administered to the animals. The livers from all the animals were taken out and cleansed. 70% alcohol was used for washing extensively, after which the liver tissue was embedded in paraffin and then 5 mm thick paraffin slices were stained by aid of hematoxylin and eosin. Results: Male rabbits were shown to be harmful to paracetamol (P<0.05). However, as compared to group 1, the levels of bilirubin, ALT, AST, and ALP were considerably higher (P<0.0001) (In the control group.) Fluvastatin (10mg/kg and 20mg/kg) combined with paracetamol resulted in significant reductions in ALP, ALT, and bilirubin levels.Slices of liver were analyzed histologically. Conclusion: Fluvastatin reduced the severity of all of these side effects, although it did not completely eliminate them. Keywords: Fluvastatin, Hepatotoxicity, Paracetamol, Hepato protection, histopathology.
Objectives: To observe the effects of Moringa Oleifera leaves extract on BPA induced changes (Diameter of hepatocytes and vacuolization) in liver of rats. Study Design: Experimental study, conducted at Post Graduate Medical Institute. Methodology: This study was performed on 32 adult rats for seven weeks. They were divided into 4 equal groups A, B, C and D. Group A was control received corn oil only. Group B, received BPA only 50mg/kg/bw. Group C and D received BPA 50mg/kg along with MoLE 250mg and 500mg. Liver was removed and was fixed in 10% formalin. To observe the effect of BPA and MoLE, slides were prepared for histological examination. For Hepatocytes, diameter and vacuolization was observed. The statistical analysis of results was done by using SPSS 21. Result: In group B, vacuolization (87.5% of animals) and statistical significant increase in mean diameter (19.7±1.3) of hepatocytes was seen. Presence of vacuoles has presumably lead to an increase in diameter . However in Groups C 50% of animals showed vacuolization and mean mean hepatocyte diameter was 17.0±1.1. In Group D 25% of animals showed vacuolization and mean mean hepatocyte diameter decreased to14.6±1 after administration of MoLE.
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