Evidence of Hepatoprotective Effect of Fluvastatin in a Rabbit Model

Abstract

Fluvastatin's hepatoprotective impact is being investigated in the current study. It is possible that the oxidative stress pathway is implicated in PCM hepatotoxicity. The acute hepatotoxicity of PCM was investigated in this study. Place of study: Rashid Latif Medical College Lahore Materials and Methods: The rabbits were divided into five groups of ten each. The saline group received (the vehicle). Fluvastatin (20 mg/kg), PCM (600 mg/kg), and PCM + 10 mg Fluvastatin (600 mg PCM + 20 mg Fluvastatin) were administered to the animals. The livers from all the animals were taken out and cleansed. 70% alcohol was used for washing extensively, after which the liver tissue was embedded in paraffin and then 5 mm thick paraffin slices were stained by aid of hematoxylin and eosin. Results: Male rabbits were shown to be harmful to paracetamol (P<0.05). However, as compared to group 1, the levels of bilirubin, ALT, AST, and ALP were considerably higher (P<0.0001) (In the control group.) Fluvastatin (10mg/kg and 20mg/kg) combined with paracetamol resulted in significant reductions in ALP, ALT, and bilirubin levels.Slices of liver were analyzed histologically. Conclusion: Fluvastatin reduced the severity of all of these side effects, although it did not completely eliminate them. Keywords: Fluvastatin, Hepatotoxicity, Paracetamol, Hepato protection, histopathology.