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BackgroundIndia has millions of tobacco users. It is the leading cause of deaths due to oral cancer and hence needs effective strategies to curb it. Hence the aim of present study was to evaluate and compare the effectiveness of Oral Health Education (OHE) and Nicotine Replacement Therapy (NRT) in tobacco cessation.Material and MethodsThe clinical trial consisted of Manohar Lal Kapoor (MLK) factory workers (n= 40) giving history of tobacco consumption (smoking/smokeless) within past 30 days. They were randomized into OHE (n=20) and NRT (n=20) groups. Baseline evaluation (demographic, smoking/ smokeless behaviour) was done. Fagerstrom test was used for Nicotine Dependence (FTND) and to assess nicotine addiction level. Follow up was done at an interval of 1week, 2 weeks, 1 month, 2 months and 3 months to assess the reduction in the mean FTND score. “Nano-CheckTM Rapid Nicotine test” was used for the qualitative detection of cotinine in human urine. Appropriate statistical analysis was performed (Paired and Unpaired t test).ResultsIn both OHE and NRT group there was a significant reduction (p< 0.00001) in mean Fagerstrom score at every follow up but when both the groups were compared mean Fagerstrom score reduction was more in NRT than OHE at all time interval though it was not statistically significant (p>0.05).ConclusionsNRT is better than OHE when both the groups were compared. However, it was found that any intervention given to tobacco users either NRT or OHE is helpful for the patients in the process of quitting tobacco. Key words:Tobacco cessation, nicotine replacement therapy, oral health education, fagerstrom test, urine cotinine.

Introduction: Tobacco is the greatest disease-producing product which is known to man and it is a primary cause of many oral diseases and adverse oral conditions. This study was conducted to bring the behavioural changes and to educate individuals about the harmful effects of tobacco. Method: Subjects reporting to the tobacco cessation centre of the Department of Public Health Dentistry and giving a history of tobacco consumption (smoking/smokeless) within past 30 day period were randomized into 2 groups: cognitive behavioural therapy (CBT) group (study group) and Basic health education (BHE) group (control group). Baseline evaluation (of demographic parameters, smoking/ smokeless behaviour) was done and Fagerstrom's test for Nicotine Dependence (FTND) was used to assess subjects' nicotine addiction levels. Follow up was done at intervals of 2 weeks and 4 weeks to assess the reduction in the mean FTND score. Appropriate statistical analysis was performed (Paired and Unpaired t-test).Results: Of all the subjects who reported to the department, 40 subjects were recruited in the study. A majority of the subjects were males who belonged to rural areas, who had completed high school and most of them had consumed more than 10 sachets of pan masala daily, for an average of 10 years. In both CBT and BHE groups, significant reductions in mean Fagerstrom scores at 1st and 2nd follow ups from baseline and between 1st and 2nd follow ups were seen. But when both groups were compared, reductions in mean Fagerstrom scores were found to be more in CBT group than in BHE group at all time intervals, though it was not statistically significant. Conclusion: Any intervention given to tobacco users from either CBT or BHE groups, helped the patients in quitting habit of tobacco.

A series of thiourea ligand , N-N'- diphenyl thiourea [I] [DPTH], N-phenyl-N'-[2-phenoyl] thiourea [II] [PPTH], N-phenyl-N'-[2-chlorophenyl] thiourea III [PCPTH], N-phenyl-N'- [5-chloro-2-methyl phenyl] thiourea IV [PCMPTH] and N- phenyl -N'-(5-chloro-2-methoxy phenyl) thiourea V (PCMTPTH) and their transition metal complexes of the type ML2 and ML2 Cl2 have been synthesized by reacting phenyl isothiocyanate with substituted aniline and transition metal salts. These newly synthesized ligands and their complexes were characterized by elemental and spectral studies. Based upon these studies it was revealed that in all the cases metal is coordinated through suphur group of thioamide of ligands. In case of nickel complexes, the nickel is coordinated to both oxygen and sulphur. In all the complexes metal is tetra coordinated forming a square planer geometry.

PurposeRenal failure is an end-stage consequence after persistent hyperglycemia during diabetic nephropathy (DN), and the etiology of DN has been linked to oxidative stress. The purpose of this research was to determine the beneficial synergistic effects of S-Allyl Cysteine (SAC) and Taurine (TAU) on oxidative damage in the kidneys of type 2 diabetic rats induced by hyperglycemia.Design/methodology/approachExperimental diabetes was developed by administering intraperitoneal single dose of streptozotocin (STZ; 65 mg/kg) with nicotinamide (NA; 230 mg/kg) in adult rats. Diabetic and control rats were treated with SAC (150 mg/kg), TAU (200 mg/kg) or SAC and TAU combination (75 + 100 mg/kg) for four weeks. The estimation of body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), oxidative stress markers along with kidney histopathology was done to investigate the antidiabetic potential of SAC/TAU in the NA/STZ diabetic group.FindingsThe following results were obtained for the therapeutic efficacy of SAC/TAU: decrease in blood glucose level, decreased level of thiobarbituric acid reactive substances (TBARS) and increased levels of GSH, glutathione-s-transferase (GST) and catalase (CAT). SAC/TAU significantly modulated diabetes-induced histological changes in the kidney of rats.Originality/valueSAC/TAU combination therapy modulated the oxidative stress markers in the kidney in diabetic rat model and also prevented oxidative damage as observed through histopathological findings.

The electrical or electronic system that can detect fire-related accidents and can alert or notify peoples, is called a Fire alarm and detection system. The fire alarm system is very important for safety in residential buildings, factories, houses, School/colleges, Hospital etc. Generally, the fire alarm system is installed in a building to detect the fire anywhere in that building. The fire alarm system has two main parts - a detection system and a notification or alarm system. Using the detection system, it senses the fire or fire-related incidents, and using the alarm system it notifies the people. Fire alarm system consists of control panel, smoke detector, MCP and Electronic Sounder. The Brain of fire alarm system is the Fire Alarm Control Panel. It is the central hub for all the detector signal to be wired and provides a status indication to the users.

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