Summary:Bone marrow transplant (BMT) recipients are prone to bacterial, viral and fungal infections. Mycobacterium tuberculosis infection can occur in these patients, but the incidence is lower than that of other infections. This report describes four patients with Mycobacterium tuberculosis infection identified from 641 adult patients who received a BMT over a 12-year period (prevalence 0.6%). The pre-transplant diagnosis was AML in two patients and CML in the other two. Pre-transplant conditioning consisted of BU/CY in three patients and CY/TBI in one. Graft-versus-host disease (GVHD) prophylaxis was MTX/CsA in three patients and T cell depletion of the graft in one patient. Sites of infection were lung (two), spine (one) and central nervous system (one). Onset of infection ranged from 120 days to 20 months post BMT. Two patients had co-existing CMV infection. One patient had graft failure. The two patients who received anti-tuberculous (TB) therapy recovered from the infection. Although the incidence of tuberculosis in BMT patients is not as high as in patients with solid organ transplants, late diagnosis due to the slow growth of the bacterium can lead to delay in instituting anti-TB therapy. A high index of suspicion should be maintained, particularly in endemic areas.

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Background: This study aimed to assess the effectiveness and safety of percutaneous needle aspiration (PNA) and percutaneous catheter drainage (PCD) in the treatment of liver abscess. Methods: A prospective randomized study was conducted in the

292ChemInform Abstract The reaction of the sterically hindered thiolate ligands with AgNO3 in the presence of triethylamine as base in acetonitrile affords the title complexes. The variation in the ligand volume influences the degree of association. Thus for the tris-silyl-substituted methylmercaptans the tetrameric (I) and trimeric compounds (II) are obtained, while for the less hindered bissilyl-substituted ligand theoctanuclear complex (III) is isolated. The relatively unhindered trimethylsilylmethylmercaptan yields a polymer (IV), consisting of chains of linked Ag4(SCH2SiMe3)4 cycles, bridged by monocyclic Ag4(SCH2SiMe3)4 groups and weakly interacting methoxy groups. The structures are determined by X-ray analysis. (I) crystallizes in the space group Pbca with Z = 8; (II) in P1, Z=2; (III) in C2/c, Z=4;and (IV) in C2/c, Z=16.

Haloalkanesulfonyl bromides including chloromethanesulfonyl bromide (1), bromomethanesulfonyl bromide (2), -bromoethanesulfonyl bromide (3), and iodomethanesulfonyl bromide (4) undergo free radical addition to olefins giving adducts which upon treatment with base afford dienes by a process termed the vinylogous Ramberg-Backlund reaction. In appropriate cases regioselectivity and/or stereoselectivity is observed in both the first addition step and in subsequent base-promoted elimination steps. Using this twoor three-step procedure, 1-alkenes are converted into 1,3-alkadienes, 2-methyl-1-alkenes into 2-alkyl-1,3-butadienes, methylenecycloalkanes into 1-vinyl-1-cycloalkenes, cycloalkenes into 3-methylene-1 -cycloalkenes, and 1 -methylcycloalkenes into 1,2-dimethylenecycloalkanes among other examples. Reagents 1-4 can also be used to convert trimethylsilyl enol ethers into -alkylidene ketones and 1,3-oxathiole 3,3-dioxides, 1,3-dienes into 1,3,5-trienes, and alkynes

A novel Rh-catalyzed cascade C–H activation/annulation of 2-arylbenzimidazoles with maleimides is reported. Rapid chemoselective access to two structurally distinct succinimide-bearing benzoimidazoisoquinolinones is achieved, depending on the acidic and basic conditions. This atom- and step-economic strategy features a wide substrate scope, excellent functional group tolerance, and site-specific functionalization. Application of the methodology yields a novel benzimidazole-based probe as a fluorescent chemosensor for the nanomolar detection of Hg2+, Cu2+, and Fe3+ ions.

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