Gastroprotective effect of cardamom, Elettaria cardamomum Maton. fruits in rats

Jamal, Anwar; Javed, Kalim; Aslam, Mohammad; Ma, Jie

doi:10.1016/j.jep.2005.07.016

Cited by 115 publications

(69 citation statements)

References 18 publications

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“…Cardamom the seeds of their ripe fruits of Elettaria cardamomum, are widely used for flavoring purposes in food and as carminative. In medicine it is used to treat gastrointestinal disorders [2]. Despite its wide uses, little information has been reported on their pharmacological properties, which showed antioxidant [3][4] and anti-inflammatory activity [5].…”

Section: Introductionmentioning

confidence: 99%

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Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Aboubakr

Abdelazem

2015

IJBAS

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The study was designed to evaluate the hepatoprotective activity of aqueous extract of cardamom in acute experimental liver injury induced by gentamicin. Twenty four male albino rats were randomly divided into four groups (six rats in each). Animals of the first group served as control and orally (p.o.) received (1 ml/kg saline). The second experimental group was given gentamicin (80 mg/kg i.p.) for 7 days. Third and fourth groups were given aqueous extract of cardamom (100 and 200 mg/kg p.o.) + gentamicin for 7 days, respectively. The degree of hepatoprotection was measured using serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, albumin, and lipid profile levels. In the acute liver damage induced by gentamicin, cardamom aqueous extracts (100 and 200 mg/kg, p.o.) significantly reduced the elevated serum levels of AST, ALT, bilirubin, cholesterol, triglycerides and low density lipoprotein cholesterol (LDL-chol) in gentamicin induced hepatotoxicity. Also cardamom aqueous extracts (100 & 200 mg/kg, p.o.) significantly increased the lowered serum levels of albumin and high density lipoprotein cholesterol (HDL-chol) in gentamicin induced hepatotoxicity rats. Histopathological examination of the liver tissues supported the hepatoprotection. Our findings concluded that cardamom aqueous extracts possessed hepatoprotective activity against gentamicin induced hepatotoxicity in rats.

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Section: Introductionmentioning

confidence: 99%

“…Antimicrobial activity of cardamom was attributed to its essential oil [6][7]. Recently, cardamom showed gastroprotective effects against aspirin and ethanol induced lesions in rats [2]. The liver is the largest internal organ in the body and played a vital role in the detoxification of harmful substances.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Aboubakr

Abdelazem

2015

IJBAS

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“…(Zingiberaceae), are widely used for flavoring purposes in food and as carminative. In Unani system of medicine it is used to treat gastrointestinal disorders (Jamal et al, 2006). Despite its wide uses little information has been reported on their pharmacological properties, which showed antioxidant (Hinneburg et al, 2006;Vasavada et al., 2006) and anti-inflammatory activity (Al-Zuhair et al., 1996).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antidiarrhoeal activity of Cardamom (Elettaria cardamomum) on mice models

Rahman¹,

Rahman²,

Rajia³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYDiarrhoea is a major health care problem in developing countries. Elettaria cardamomum Maton fruits, commonly known as cardamom are widely used for flavoring purposes in food. In this study we evaluated the antidiarrhoeal activity of hot water extract of cardamom against experimental diarrhoeal models on mice. Cardamom extract showed significant antidiarrhoeal activity against castor oil and magnesium sulphate induced models. Whereas, the gastrointestinal motility was slightly increased.

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“…Moreover, eugenol has been reported to possess gastroprotective activity (Santin et al, 2011). The fruits of E. cardamomum reportedly also demonstrated gastroprotective activity against gastric lesions induced by aspirin, ethanol and pyloric ligature in rats; the fruits are also used in the Unani system of medicine to treat gastrointestinal disorders (Jamal et al, 2006). It is possible that the Kanda healer's use of the three spices may be to ameliorate any gastrointestinal disturbances caused by fever, or to ameliorate any gastrointestinal disturbances caused by administration of R. serpentina roots.…”

Section: Discussionmentioning

confidence: 99%

Medicinal formulations of a Kanda tribal healer – a tribe on the verge of disappearance in Bangladesh

Rahmatullah

Ayman²,

Akter³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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The Kanda tribe is one of the lesser known small tribes of Bangladesh with an estimated population of about 1700 people (according to them), and on the verge of extinction as a separate entity. To some extent, they have assimilated with the surrounding mainstream Bengali-speaking population, but they still maintain their cultural practices including traditional medicinal practices, for which they have their own tribal healers. Nothing at all has been documented thus far about their traditional medicinal practices and formulations, which are on the verge of disappearance. The Kanda tribe can be found only in scattered tea gardens of Sreemangal in Sylhet district of Bangladesh; dispersion of the tribe into small separated communities is also contributing to the fast losing of traditional medicinal practices. The objective of the present study was to conduct an ethnomedicinal survey among the traditional healers of the Kanda tribe (in fact, only one such healer was found after extensive searches). Information was collected from the healer with the help of a semi-structured questionnaire and the guided field-walk method. A total of 24 formulations were obtained from the healer containing 34 plants including two plants, which could not be identified. Besides medicinal plants, the Kanda healer also used the body hairs of the Asiatic black bear (Ursus thibetanus) and bats (Pteropus giganteus giganteus) in one of his formulation for treatment of fever with shivering. The ailments treated by the Kanda healer were fairly common ailments like cuts and wounds, skin diseases, helminthiasis, fever, respiratory problems (coughs, asthma), gastrointestinal disorders (stomach pain, constipation, diarrhea), burning sensations during urination, various types of pain (headache, body ache, toothache, ear ache), conjunctivitis, poisonous snake, insect or reptile bites, jaundice, and bone fractures. A number of important drugs in allopathic medicine like quinine, artemisinin, and morphine (to name only a few) have been discovered from observing indigenous medicinal practices. From that view point, the formulations used by the Kanda healer merit scientific studies for their potential in the discovery of cheap and effective new drugs. Scientific validation of the medicinal formulations of the Kanda healer can also be effective for treatment of ailments among this tribe, which does not have or does not want to have any contact with modern medicine.

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Gastroprotective effect of cardamom, Elettaria cardamomum Maton. fruits in rats

Cited by 115 publications

References 18 publications

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Evaluation of antidiarrhoeal activity of Cardamom (Elettaria cardamomum) on mice models

Medicinal formulations of a Kanda tribal healer – a tribe on the verge of disappearance in Bangladesh

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