The present study uses a review of the literature and the views of tourism and management professors and experts in order to the identification of organizational intelligence elements in tourism management (STO) for the first time. The census method was used to determine the research sample and the Delphi technique was used to design the questionnaire. Construct divergence was then used to determine the validity and reliability of the questionnaire. The final results indicated that providing e-services for tourists had the greatest impact on the development of STO (loading factor: 0.677). Moreover, New Tourism Marketing Methods (NTMM) had the least effect on the development of STO (loading factor: 0.431). Overall, the most important achievement of the present research is introducing the concept of STO in tourism management.
Myocardial infarction is one of the most prevalent diseases around the world. Cardiac tissue engineering is a new approach to repair and revive the structure and functionality of cardiac damaged tissue. In this study, gellan gum/reduced graphene oxide composite hydrogels were fabricated, characterized, and evaluated. The hydrogels were prepared using the solvent casting method and characterized via scanning electron microscopy and Fourier-transform infrared spectroscopy. Compressive mechanical analysis, injectability as well as electrical conductivity test were run. Furthermore, water swelling and degradation analyses were conducted. MTT assay was performed using rat myoblasts (H9C2) to determine the cytotoxicity of our samples. Results showed that reduced graphene oxide fillers dispersed acceptably and enhanced the compressive modulus and electrical conductivity of gellan gum hydrogels. However, in this regard, compressive strength and ductility were not significantly boosted with reduced graphene oxide addition. The water-swelling ratio (%) rised in the presence of reduced graphene oxide, whereas the degradation rate was not significantly affected by them. Meanwhile, synthesized hydrogels showed suitable injectability. MTT assay results revealed that gellan gum hydrogels containing 1% and 2% reduced graphene oxide were not cytotoxic. According to the findings, gellan gum/2% reduced graphene oxide composite hydrogel can be a promising candidate for repairing and healing infarcted myocardial tissue.
Novel drug delivery systems have ameliorated drugs’ pharmacokinetics and declined undesired ramifications while led to a better patient compliance by extending the time of release. In fact, although there has been a multitude of encouraging achievements in controlled drug release, the application of micro- and nano-carriers is confronted with some challenges such as rapid clearance and inefficient targeting. In addition, since cell systems can be an appropriate alternative to micro- and nano-particles, they have been used as biological carriers. In general, features such as stable release into blood, slow clearance, efficient targeting, and high biocompatibility are the main properties of cells applied as drug carriers. Furthermore, some cells such as erythrocytes, leukocytes, stem cells, and platelets have been used as release systems. Hence, most common cells that were used as aforementioned release systems are going to be presented in this review article.
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