Four isomerically pure octasubstituted zinc phthalocyanines with variations in the attachment atom and positions of the substituents were selected for a systematic investigation of the effect of the substitution pattern on their electronic and spectroscopic properties. Effects which were investigated are the position, the electron donating and withdrawing properties, and the donating force of the substituent. The results are discussed and interpreted based on theoretical and experimental determination of the orbital levels. This work allows us to highlight which substitution patterns are the most suitable considering different common applications of phthalocyanines.

A novel BODIPY derivative was designed for biomedical applications. Its mono-quaternized structure ensured its water-solubility and suitable amphiphilicity. Showing no singlet oxygen generation to avoid damage to healthy cells, this new derivative proved to be an extremely promising antimicrobial agent, with activity equal or superior to ampicillin against MRS Staphylococcus strains with no short-term resistance issue. Its activity against MSS Staphylococcus strains was largely superior to those of ampicillin and reached the activity of vancomycin against MSS S. epidermidis. This latter result is in particular extremely promising for the treatment of hospital-acquired infections. Also the fluorescence properties of BODIPY allowed imaging of the uptake.

In this study, a series of novel silicon (IV) phthalocyanines conjugated axially with anti-inflammatory (sulindac) and triethylene glycol groups has been synthesized. Different synthetic strategies were attempted to obtain the targeted molecules in high yield. The compounds were fully characterized by using different analyses techniques. Our objectives were to generate a system with sulindac group which enhances the singlet oxygen generation and exhibits anti-cancer effect. Therefore, photophysical and photochemical properties of these compounds were investigated in different solvents. The substituent effect on fluorescence quantum yield and singlet oxygen generation was evaluated for efficiency in photodynamic therapy (PDT) as photosensitizer. The molecules exhibited no aggregation tendency, solubility in common organic solvents, high singlet oxygen quantum yield and high photostability in DMSO so these favourable properties make them good candidates as photosensitizer for PDT. In addition, their stabilities were investigated in DMSO, THF, acetonitrile and DMF.

Room temperature phosphorescent oxygen sensors have been designed by embedding symmetric palladium(ii) or platinum(ii) meso-tetraphenylporphyrins in poly(1-trimethylsilyl-1-propyne) in the form of nanofibers along with/without silver nanoparticles.

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High oxygen permeable [poly(TMSP)] nanofibers incorporating porphyrin macrocycle as luminescence indicators were prepared by electrospinning technique. The porphyrins involves were modified by i) introducing phenylacetylide substituents on the para position of the phenyl moieties and ii) varying the metal centers [Pt(II) or Pd(II)] of the meso-tetrakisphenylporphyrins. A set of nanofibers; (Pt-TPP)NF, (Pd-TPP)NF, (Pt-TPA)NF and (Pd-TPA)NF were obtained to study their structure-activity relationship toward oxygen. The lifetime-based technique was privileged to take advantage of their long-lived phosphorescent properties. A two-fold enhancement was observed for (Pt-TPA)NF and (Pd-TPA)NF compared to (Pt-TPP)NF and (Pd-TPP)NF demonstrating the positive effect of the phenylacetylide moieties on the lifetime. Also, Silver nanoparticles were included in nanofibers to investigate their influence on lifetime-based oxygen sensitivity, showing that the presence of AgNPs only affects (Pd-TPA)NF.

Emission-based oxygen sensing properties of highly luminescent tetraphenylporphyrin molecules were investigated in polystyrene, ethyl cellulose, poly(1-trimethylsilyl-1-propyne) and poly(isobutylmethacrylate) matrices. The effect of perfluorochemicals (PFCs) on oxygen sensitivity and stability of the sensor materials was also examined. Fluorescence intensity and lifetime measurements of meso-tetraphenylporphyrinato Zn ( II ) (ZnTPP) and meso-tetraphenylporphyrin (H2TPP) materials were performed in the concentration range of 0–100% pO 2. The fluorescence intensity variation of H2TPPvs. oxygen was 86%. H2TPP-based composite also yielded higher Stern–Volmer constant, faster response and regeneration time, excellent long term photostability and larger linear response range with respect to ZnTPP. The detection limit of oxygen for H2TPP was less than 0.5%. When stored in sealed bags protected from sunlight, no decrease in oxygen sensitivity was observed during approximately five months. As far as we know, the gathered utilization of PFCs and H2TPP embedded in polymer matrices was not previously described in literature, and has present amelioration compared to materials already existing.

New synthetic route and PDT potential of symmetrically and asymmetrically substituted Ga(iii)Pcs with terminal azides.