Lifetime-Based Oxygen Sensing Properties of palladium(II) and platinum(II) meso-tetrakis(4-phenylethynyl)phenylporphyrin

Önal, Emel; Sass, Stephan; Hurpin, Jeanne; Ertekin, Kadriye; Topal, Sevinç Zehra; Kumke, Michael U.; Hirel, Catherine

doi:10.1007/s10895-016-2022-x

Cited by 22 publications

(9 citation statements)

References 21 publications

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“…These microhybrid materials showed enhanced quantum yield and higher sensitivity to O 2 providing a low limit of detection extending to 7.5 ppm. The authors also reported the lifetime based oxygen sensing properties of such phenylacetylide porphyrin nanofibres (Önal et al, 2017 ). The oxygen partitions (0.86–0.99) indicate an exceptional permeation of O 2 and the K SV values confirm an extreme sensitivity of the nanofibres to oxygen which can be detected by studying the variation of lifetime decays at different O 2 concentrations.…”

Section: Optical Sensing Approaches: the Role Of Oxygen Quenchingmentioning

confidence: 99%

Oxygen Sensing, Hypoxia Tracing and in Vivo Imaging with Functional Metalloprobes for the Early Detection of Non-communicable Diseases

2018

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Hypoxia has been identified as one of the hallmarks of tumor environments and a prognosis factor in many cancers. The development of ideal chemical probes for imaging and sensing of hypoxia remains elusive. Crucial characteristics would include a measurable response to subtle variations of pO2 in living systems and an ability to accumulate only in the areas of interest (e.g., targeting hypoxia tissues) whilst exhibiting kinetic stabilities in vitro and in vivo. A sensitive probe would comprise platforms for applications in imaging and therapy for non-communicable diseases (NCDs) relying on sensitive detection of pO2. Just a handful of probes for the in vivo imaging of hypoxia [mainly using positron emission tomography (PET)] have reached the clinical research stage. Many chemical compounds, whilst presenting promising in vitro results as oxygen-sensing probes, are facing considerable disadvantages regarding their general application in vivo. The mechanisms of action of many hypoxia tracers have not been entirely rationalized, especially in the case of metallo-probes. An insight into the hypoxia selectivity mechanisms can allow an optimization of current imaging probes candidates and this will be explored hereby. The mechanistic understanding of the modes of action of coordination compounds under oxygen concentration gradients in living cells allows an expansion of the scope of compounds toward in vivo applications which, in turn, would help translate these into clinical applications. We summarize hereby some of the recent research efforts made toward the discovery of new oxygen sensing molecules having a metal-ligand core. We discuss their applications in vitro and/or in vivo, with an appreciation of a plethora of molecular imaging techniques (mainly reliant on nuclear medicine techniques) currently applied in the detection and tracing of hypoxia in the preclinical and clinical setups. The design of imaging/sensing probe for early-stage diagnosis would longer term avoid invasive procedures providing platforms for therapy monitoring in a variety of NCDs and, particularly, in cancers.

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Section: Optical Sensing Approaches: the Role Of Oxygen Quenchingmentioning

confidence: 99%

Oxygen Sensing, Hypoxia Tracing and in Vivo Imaging with Functional Metalloprobes for the Early Detection of Non-communicable Diseases

2018

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“…Another approach for maintaining long-lived phosphorescent properties involved the introduction of phenylacetylide substituents in the para position of the phenyl moieties of Pt-tetraphenylporphyrin, further incorporated in several polymers, with the purpose of improving the luminescence lifetime-based oxygen sensitivity [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Potentiometric Sensors for Iodide and Bromide Based on Pt(II)-Porphyrin

Vlascici

Pleşu

Făgădar-Cosma

et al. 2018

Sensors

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Pt(II) 5,10,15,20-tetra(4-methoxy-phenyl)-porphyrin (PtTMeOPP) was used in the construction of new ion-selective sensors. The potentiometric response characteristics (slope and selectivity) of iodide and bromide-selective electrodes based on (PtTMeOPP) metalloporphyrin in o-nitrophenyloctylether (NPOE), dioctylphtalate (DOP) and dioctylsebacate (DOS) plasticized poly(vinyl chloride) membranes are compared. The best results were obtained for the membranes plasticized with DOP and NPOE. The sensors have linear responses with near-Nernstian slopes toward bromide and iodide ions and good selectivity. The membrane plasticized with NPOE was electrochemically characterized using the EIS method to determine its water absorption and the diffusion coefficient into the membrane.

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“…The detection is based on the reversible fluorescence response of the Pt-porphyrin to different concentrations of dissolved O 2 in water. Based on the same method, other platinum fluorescent compound, Pt(II)-5-(3-aminophenyl)-10,15,20-tris-(p-tolyl)-porphyrin, incorporated in polyimide polymers was capable of detecting oxygen in concentrations up to 10% [7].Composite strips comprising Pt(II)-meso-tetrakis-(pentafluorophenyl)-porphyrin and cadmium telluride quantum dots were used for rapid colorimetric determination [8,9] of oxygen. High fluorescence quantum yield hybrid materials based on phenylacetylide fibers functionalized with platinum (II) meso-tetraphenylporphyrins were developed and showed improved sensitivity to O 2 , providing a detection limit of 7.5 ppm.…”

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confidence: 99%

“…High fluorescence quantum yield hybrid materials based on phenylacetylide fibers functionalized with platinum (II) meso-tetraphenylporphyrins were developed and showed improved sensitivity to O 2 , providing a detection limit of 7.5 ppm. The response to oxygen detection was significantly improved by adding silver nanoparticles to the hybrid material [9]. A recent work [10] showed that Pt (II)-complex with octaethylporphyrin-ketone is a near-infrared spectroscopy (NIR) emitting oxygen indicator.Pt-porphyrins have been used extensively in polymeric membranes to detect molecular oxygen, but because of their small tendency to bind axial ligands [11,12] they have not been largely investigated as ionophores [13].…”

mentioning

confidence: 99%

“…Composite strips comprising Pt(II)-meso-tetrakis-(pentafluorophenyl)-porphyrin and cadmium telluride quantum dots were used for rapid colorimetric determination [8,9] of oxygen. High fluorescence quantum yield hybrid materials based on phenylacetylide fibers functionalized with platinum (II) meso-tetraphenylporphyrins were developed and showed improved sensitivity to O 2 , providing a detection limit of 7.5 ppm.…”

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confidence: 99%

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Novel Platinum-Porphyrin as Sensing Compound for Efficient Fluorescent and Electrochemical Detection of H2O2

et al. 2020

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Metalloporphyrins are highly recognized for their capacity to act as sensitive substances used in formulation of optical, fluorescent, and electrochemical sensors. A novel compound, namely Pt(II)-5,10,15,20-tetra-(4-allyloxy-phenyl) porphyrin, was synthesized by metalation with PtCl2(PhCN)2 of the corresponding porphyrin base and was fully characterized by UV-vis, fluorimetry, FT-IR, 1H-NMR, and 13C-NMR methods. The fluorescence response of this Pt-porphyrin in the presence of different concentrations of hydrogen peroxide was investigated. Besides, modified glassy carbon electrodes with this Pt-porphyrin (Pt-Porf-GCE) were realized and several electrochemical characterizations were comparatively performed with bare glassy carbon electrodes (GCE), in the absence or presence of hydrogen peroxide. The Pt-porphyrin demonstrated to be a successful sensitive material for the detection of hydrogen peroxide both by fluorimetric method in a concentration range relevant for biological samples (1.05–3.9 × 10−7 M) and by electrochemical method, in a larger concentration range from 1 × 10−6 M to 5 × 10−5 M. Based on different methods, this Pt-porphyrin can cover detection in diverse fields, from medical tests to food and agricultural monitoring, proving high accuracy (correlation coefficients over 99%) in both fluorimetric and electrochemical measurements.

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Lifetime-Based Oxygen Sensing Properties of palladium(II) and platinum(II) meso-tetrakis(4-phenylethynyl)phenylporphyrin

Cited by 22 publications

References 21 publications

Oxygen Sensing, Hypoxia Tracing and in Vivo Imaging with Functional Metalloprobes for the Early Detection of Non-communicable Diseases

Oxygen Sensing, Hypoxia Tracing and in Vivo Imaging with Functional Metalloprobes for the Early Detection of Non-communicable Diseases

Potentiometric Sensors for Iodide and Bromide Based on Pt(II)-Porphyrin

Novel Platinum-Porphyrin as Sensing Compound for Efficient Fluorescent and Electrochemical Detection of H2O2

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