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Objective: The purpose of our study was to examine the effect of melatonin (MLT) on wound healing in the nasal septum. Methods: Twenty-two Sprague–Dawley rats of the male sex were included in this experimental study. Nasal septal perforation (NSP), about two millimeters in diameter, was formed in each rat. Melatonin was applied to the subjects in the study group and saline was applied to the subjects in the control group once a day for 14 days. On day 14, the rats were sacrificed and the nasal septums of the subjects were resected for pathological evaluation. In the NSP area, degeneration and regeneration of nasal septal epithelium, degeneration and regeneration of the septal cartilage, number of cells involved in wound healing such as acute inflammatory cells (leukocytes), fibroblast, eosinophil, and giant cell, capillary vessel intensity, granulation tissue formation, collagen intensity parameters were evaluated histopathologically. The macroscopic size and histopathologic examination results of NSPs were statistically analyzed. Results: In the MLT group, the epithelium regeneration, the cartilage regeneration, fibroblast number, collagen density, vascularity, and granulation formation were significantly higher, and the epithelial degeneration and acute inflammatory cells density were significantly lower, in the NSP area (p<0.05). In addition, the macroscopic healing was significantly higher in the MLT group (p= 0.044, p<0.05) Conclusion: The local application of melatonin accelerates nasal septal wound healing. With this feature, melatonin may use to prevent the formation of NSP.

The aim of the present experimental animal study was to investigate the efficacy of bovine lactoferrin (LF) on wound healing in an animal model of nasal septum perforation (NSP).Twenty-two, 8 to 10 weeks of age, male Sprague-Dawley rats were separated into two groups. Nasal septum perforation was created in each rat. The saline (control) and 0.05 mg LF (study) groups were delivered locally for 14 days. On the 14th day of the study, after the sacrifice, the cartilage nasal septa of the animals were excised. The degeneration and regeneration observed in the nasal septum epithelium and cartilage, the number of acute inflammatory cells, the number of eosinophils, the amount of new vessel formation, the amount of granulation, and the collagen density were examined microscopically. The microscopic parameters and macroscopic healing of NSPs were analyzed. The epithelium regeneration, the fibroblast number, the granulation tissue formation, the collagen density, and the macroscopic healing were significantly higher in the LF group (p < 0.05). Besides, the acute inflammatory cell count was lower in the LF group (p = 0.034). In conclusion, the topically delivered LF can improve wound healing in an experimental rat model of NSP.

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Anahtar Sözcükler: Fistül, kist, sistrunk operasyonu Aim: In this study, we aimed to discuss the examination findings, clinical features and treatment methods in 72 patients, who were operated for thyroglossal duct cyst, in the light of the relevant literature. Methods:We retrospectively analyzed the medical reports of 72 patients who were operated due to thyroglossal duct cyst in our clinic.Results: Forty-eight patients were male and 24 were female. The age at presentation ranged from 10 to 56 years (average age: 16.8±15.7 years). The most common complaint was fistula point at the middle region of the neck (58%). Rarely, a nodule or intermittent secretion was being at the middle of the neck in patients. Fistula point or nodule was settled at the midline of the neck and thyrohyoid zone in 16 patients. Clinic presentation was a fistula in 38 patients and a cyst in 34 patients. Sistrunk operation was performed in all patients.Conclusion: Thyroglossal duct cyst should be considered in the differential diagnosis of patients presenting with neck swelling and discharge from the midline. Thyroglossal duct cysts should be treated surgically due to the risk of malignant transformation. Sistrunk surgery, with its low recurrence rate and low risk of complications, is the gold standard in the treatment of thyroglossal duct cysts. Keywords: Fistulas, cysts, sistrunk operation Abs tractYa z›fl maAd re si/Ad dressforCor res pon den ce:Cemal Hacı

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