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The specific design of the mobile dedicated intraoperative radiotherapy (IORT) accelerators and different electron beam collimation system can change the dosimetric characteristics of electron beam with respect to the conventional accelerators. The aim of this study is to measure and compare the dosimetric characteristics of electron beam produced by intraoperative and conventional radiotherapy accelerators. To this end, percentage depth dose along clinical axis (PDD), transverse dose profile (TDP), and output factor of LIAC IORT and Varian 2100C/D conventional radiotherapy accelerators were measured and compared. TDPs were recorded at depth of maximum dose. The results of this work showed that depths of maximum dose, R90,R50, and RP for LIAC beam are lower than those of Varian beam. Furthermore, for all energies, surface doses related to the LIAC beam are substantially higher than those of Varian beam. The symmetry and flatness of LIAC beam profiles are more desirable compared to the Varian ones. Contrary to Varian accelerator, output factor of LIAC beam substantially increases with a decrease in the size of the applicator. Dosimetric characteristics of beveled IORT applicators along clinical axis were different from those of the flat ones. From these results, it can be concluded that dosimetric characteristics of intraoperative electron beam are substantially different from those of conventional clinical electron beam. The dosimetric characteristics of the LIAC electron beam make it a useful tool for intraoperative radiotherapy purposes.PACS number: 87.56.‐v, 87.56.bd

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It was demonstrated that iron oxide nanoparticles with the appropriate surface modifications can enter the DU145 cells and it can be used as a cell sensitizer to megavoltage ionizing radiations in radiation therapy.

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In this paper the effect of treatment room and maze layout on the photoneutron and capture gamma dose equivalent in the maze was studied. MCNPX Monte Carlo (MC) code was used to simulate the Varian 2100 C/D Clinac 18 MV and four different room layouts. Two analytical methods, Wu-McGinley and McGinley, were used for dose calculations. The analytical methods overestimated the photoneutron dose (13-43 %) and gamma capture dose (16-95 %) comparing with the MC method at the maze entrance door. The results of MC method revealed that additional bend can cause a great reduction in photoneutron (5000 times) and capture gamma dose (50 times) in the maze entrance door.

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