In two young patients with acute hepatic porphyria syndrome and persisting paralyses, which increased in intensity during intermittent occurring crisis, the activity of erythrocyte porphobilinogen synthase (delta-aminolevulinic acid dehydratase) was found to be considerably diminished, below 1% of the value of normal control persons. In contrast, the activity of uroporphyrinogen synthase was normal. Both patients have been excreting high quantities of delta-aminolevulinic acid and porphyrins in urine for years. Lead intoxication has definitively been excluded. Since the relatives also show lower activities in porphobilinogen synthase, the disease of these two patients is probably a new enzymatic type of inherited acute hepatic porphyria, the excretion profile of which is qualitatively completely different from those of the known acute porphyrias. The discovery of this porphyria confirms the theory of overlapping transition in the biochemical and clinical symptoms and analogies among acute hepatic porphyrias.
The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.
The relationship between filtration rate (GFR) and electrolyte excretion was investigated during infusions of low doses of angiotensin II (0.02 to 2.0 µg/sq m/min) by means of repeated clearance experiments in trained normal, adrenalectomized, and chronic experimental renal hypertensive dogs. A limited number of experiments were conducted also in dogs anesthetized with pentobarbital. Parameters of BP, CIn, CpAH, UNa, and Uk were determined simultaneously under conditions of a moderate water diuresis. Alterations in GFR were produced by varying the dose of angiotensin, thereby allowing a study of electrolyte excretion under conditions of decreased, relatively unchanged, and increased filtered loads. The data was grouped for statistical analysis on the basis of whether the change in GFR from control was more than –5%, within ± 5%, or above +5%. Sodium excretion (UNaV) was found to parallel the change in GFR in the three types of dogs. Potassium excretion (UkV) showed also a relationship with GFR in the normal and hypertensive dogs but fell significantly below control in the adrenalectomized dogs when GFR remained at control levels (within ± 5%). Significant alterations in tubular sodium transport were not apparent at the low doses of angiotensin used in this study. A dampened renal vasomotor response was observed in the hypertensive dogs which was associated with a greater tendency of GFR to increase above control. It is concluded that under the conditions of this study low doses of angiotensin can produce a decrease, no change, or an increase in the excretion of sodium as a result of the drug’s action on the renal vascular bed to alter GFR.
The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.