Renal autoregulation and renin release during changes in renal perfusion pressure

He, Schmid

doi:10.1152/ajplegacy.1972.222.5.1132

Cited by 36 publications

(23 citation statements)

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“…Renal vascular resistance increased from 0.36 to 0.61 and 0.95 PRU as renal arterial pressure was raised from 50 to 100 and from 100 to 163 mm Hg. These experiments confirm the previously demonstrated dissociation between renal vascular resistance and renin release (4,5). Figure 2 depicts the mean change in renal blood flow per mean change in renal arterial pressure for groups 1 and 2.…”

supporting

confidence: 87%

“…Since the kidney is completely isolated, the influence of renal nerve activity is eliminated. In contrast to most other studies of autoregulation (4)(5)(6)(7)(8)(21)(22)(23), this technique allows the examination of the response to a standard pressure stimulus over a uniform pressure range and excludes the possibility that extrarenal factors related to aortic constriction, vagotomy, carotid sinus denervation, or carotid occlusion influence the response.…”

Section: Renin Depletion and Autoregulationmentioning

confidence: 99%

“…Evidence against this hypothesis includes the well-established fact that renal renin secretion, reflected by renal vein renin activity (4,5), and angiotensin II formation, reflected by the concentration of this peptide in renal hilar lymph (6), change in a direction opposite to that which would be anticipated if the renin-angiotensin system were mediating the alterations in renal vascular resistance associated with the autoregulatory response. In addition, several groups of investigators have demonstrated that autoregulation persists in the presence of angiotensin II infusions albeit at a higher level of renal vascular resistance (7)(8)(9).…”

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confidence: 99%

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Impaired Autoregulation of Blood Flow and Glomerular Filtration Rate in the Isolated Dog Kidney Depleted of Renin

Kaloyanides

Bastron

DiBona

1974

Circulation Research

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The effect of renin depletion on autoregulation of renal blood flow and glomerular filtration rate was examined in an isolated perfused kidney preparation. Group 1 dogs received a normal-sodium diet, group 2 dogs received deoxycorticosterone acetate (DOCA) and a high-sodium diet, group 3 dogs received DOCA and a sodium-deficient diet, group 4 dogs received a high-sodium diet without DOCA, and dogs in groups 5 and 6 were treated just like dogs in groups 1 and 2, respectively. Renin release was stimulated by decreasing renal'arterial pressure to 50 mm Hg. An increase in renal arterial pressure from 100 to 160 mm Hg was associated with an impaired autoregulatory response in kidneys from group 2 dogs and in two kidneys from group 4 dogs; these kidneys exhibited suppressed or absent renin release in response to a decrease in renal arterial pressure.A separate group of experiments demonstrated that DOCA plus a high-sodium diet completely depleted the kidney of renin stores, indicating that decreased renin secretion reflected depletion of renal renin content. Infusing angiotensin II (0.22 ± 0.06 jtg/min) into the renal artery of group 2 kidneys did not normalize the autoregulatory response. A decrease in renal arterial pressure from 150 to 50 mm Hg was associated with impaired autoregulation of glomerular filtration rate and renal blood flow in kidneys from group 6 dogs; renin secretion was undetectable in these kidneys. All kidneys from groups 1, 3, and 5 and the remaining six kidneys from group 4 exhibited a normal autoregulatory response and normal renin release. In groups 1-3, zonal blood flow was measured using the radiolabeled microsphere technique. Only in group 2 did a significant redistribution of fractional blood flow from the inner to the outer cortex occur. These experiments demonstrate that renin depletion impairs the capacity of the kidney to autoregulate blood flow and glomerular filtration rate; thus the data are consistent with the hypothesis that the reninangiotensin system participates in the autoregulatory response. KEY WORDS renin secretion arterial pressurerenin-angiotensin system deoxycorticosterone renal blood flow distribution renal vascular resistance sodium diet• Autoregulation of renal blood flow refers to the phenomenon whereby renal blood flow remains relatively constant as renal perfusion pressure is varied over the range of 80 to about 180 mm Hg. Constancy of renal blood flow requires changes in renal vascular resistance that parallel changes in renal perfusion pressure. The mechanism by which renal vascular resistance is altered remains a subject of controversy. Thurau and co-workers (1, 2) have proposed that the renin-angiotensin systemFrom the Departments of Medicine and Anesthesiology. University of Iowa College of Medicine, and the Medicine and Research and Education Services, Veterans Administration Hospital, Iowa City, Iowa 52240.This work was supported in part by U. S. Public Health Service Grants HL 13754, AM 15843. and HL 014388 from the National Institutes of Health an...

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supporting

confidence: 87%

Section: Renin Depletion and Autoregulationmentioning

confidence: 99%

mentioning

confidence: 99%

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Impaired Autoregulation of Blood Flow and Glomerular Filtration Rate in the Isolated Dog Kidney Depleted of Renin

Kaloyanides

Bastron

DiBona

1974

Circulation Research

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“…Other investigators (2,20,25) have not observed an increase in renin with decreases in carotid sinus pressure. Lower body suction (application of subatmospheric pressure) was produced by enclosing the lower part of the subject's body caudal to the iliac crests in an airtight chamber (33).…”

mentioning

confidence: 83%

Influence of low- and high-pressure baroreceptors on plasma renin activity in humans

Mark¹,

Abboud²,

Fitz³

1978

American Journal of Physiology-Heart and Circulatory Physiology

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We evaluated effects of the low- and high-pressure baroreceptors on plasma renin activity (immunoassay) using graded lower body suction (LBS) in six healthy men. LBS at -10 and -20 mmHg for 10 min decreased central venous pressure without changing arterial pressure and thereby presumably reduced low- but not high-pressure baroreceptor inhibition of renin release. LBS at these levels produced forearm vasoconstriction, but did not increase renin. LBS at -40 mmHg decreased central venous and arterial pulse pressure and thus reduced both low- and high-pressure baroreceptor inhibition. LBS at this level produced forearm vasoconstriction and tachycardia and increased renin from 2.1 +/- 0.4 (mean +/- SE to 7.4 +/- 1.4 ng.ml-1.h-1 (P less than 0.05). In summary, reduction in low-pressure baroreceptor inhibition in humans did not increase renin in the presence of physiological tonic inhibition from high-pressure baroreceptors. Increases in renin did not occur until there was combined reduction of high- and low-pressure baroreceptor inhibition on plasma renin activity.

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“…16 The above findings can explain the previous divergent observations on the effects of carotid sinus hypotension on the secretion of renin. In two of the three studies in which renin secretion was not influenced by the carotid baroreflex, the vagi were intact and renal perfusion either was not controlled 14 or not controlled in every experiment. 15 In the third study, the dogs were vagotomized but renal arterial pressure was not controlled.…”

Section: Discussionmentioning

confidence: 99%

Release of renin by the carotid baroreflex in anesthetized dogs. Role of cardiopulmonary vagal afferents and renal arterial pressure.

Jarecki¹,

Thorén²,

Donald³

1978

Circulation Research

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SUMMARY In 3 of 10 anesthetized dogs with aortic nerves sectioned and renal arterial pressure maintained constant, reduction to 40 mm Hg of the pressure in the vascularly isolated carotid sinuses resulted in an increase in renin secretion. After section of the vagus nerves, carotid sinus hypotension resulted in an increase in renin secretion in 9 of the 10 dogs. Vagal nerve section in these 10 dogs with carotid sinuses vascularly isolated and maintained at a pressure equal to existing aortic pressure resulted in significant increases in basal levels of plasma renin activity and renin secretion. The increase in renin secretion found during carotid sinus hypotension in vagotomized dogs was totally or substantially inhibited when renal arterial pressure was not maintained constant but allowed to increase equally with systemic arterial pressure. The increase in renin secretion observed during carotid hypotension in vagotomized dogs with renal arterial pressure held constant was abolished by renal denervation. We conclude that the carotid baroreflex is involved in the neural control of renin release. However, a concomitant activation of cardiopulmonary receptors and/or a substantial rise in renal arterial pressure can suppress the reflex increase in the secretion of renin induced by carotid sinus hypotension. have shown that the release of renin in such diverse situations as suprarenal aortic stenosis, administration of the diuretic furosemide, and tilting to the upright position is dependent on neural mechanisms in considerable degree. In view of these observations, it is surprising to find disagreement regarding the role of the carotid baroreflex in the control of renin secretion. Three studies"*" 12 reported an increase in renin secretion during carotid occlusion and three studies 13 " 15 reported that renin secretion was not affected by changes in carotid sinus pressure. IN THE LAST FEW YEARS increasing attention hasIn a recent study it was shown that, when the carotid sinus was free to exert its buffering influence, complete interruption of afferent vagal nerve traffic from cardiopulmonary receptors did not result in an increase in renin secretion in 17 of 20 dogs. 16 Because it has been shown that the inhibitory influence of vagally innervated cardio- pulmonary receptors becomes more pronounced as that of the carotid baroreceptors is reduced," it seemed possible that this interaction between the two receptor systems might act to inhibit the release of renin during carotid sinus hypotension. The following studies were carried out to investigate this question. MethodsDogs weighing 16-20 kg were maintained on a daily intake of 65 mEq of Na + and 55 mEq of K + for 5 days before study. Anesthesia was induced with sodium thiopental (30 mg/kg, intravenously) followed by a-chloralose (80 mg/kg dissolved in 5% dextrose in water and administered intravenously). Supplemental doses of chloralose (5-10 mg/kg) were given hourly. Gallamine triethiodide (Flaxedil; 3 mg/kg, iv) was used to obtain muscle relaxation during the su...

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Renal autoregulation and renin release during changes in renal perfusion pressure

Cited by 36 publications

References 0 publications

Impaired Autoregulation of Blood Flow and Glomerular Filtration Rate in the Isolated Dog Kidney Depleted of Renin

Impaired Autoregulation of Blood Flow and Glomerular Filtration Rate in the Isolated Dog Kidney Depleted of Renin

Influence of low- and high-pressure baroreceptors on plasma renin activity in humans

Release of renin by the carotid baroreflex in anesthetized dogs. Role of cardiopulmonary vagal afferents and renal arterial pressure.

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