Renin release, renal autoregulation, and sodium excretion in the dog

Fojas, JE; He, Schmid

doi:10.1152/ajplegacy.1970.219.2.464

Cited by 33 publications

(11 citation statements)

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“…This behavior could also be observed in a series of experiments with normal dogs not reported in this communication and is in agreement with the literature [19,20],…”

Section: Resultssupporting

confidence: 93%

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The Influence of Renin on the Intrarenal Distribution of Blood Flow and Autoregulation

Brech¹,

Sigmund²,

Kadatz³

et al. 1974

Nephron

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The influence of the renin-angiotensin system on renal autoregulation and intrarenal distribution of blood flow was studied in 10 dogs. Using a femoral-renal bypass, total renal blood flow and perfusion pressure were determined under basal conditions and after graded renal arterial constriction. At each pressure level renal venous renin activity and the distribution of renal blood flow (Xe¹³³-washout technique) were determined. In 4 dogs these studies were done after renin depletion by high sodium intake and injections of DOCA. Renal autoregulation of blood flow was abolished in renin-depleted animals. During reduction of renal perfusion pressure in the lower autoregulatory range or below, a redistribution of intrarenal perfusion could be observed from outer cortical to inner cortical-juxtamedullary compartments. The redistribution was more pronounced in renin-depleted than in normal animals. In normal dogs, reduction of perfusion pressure resulted in an increase in outer cortical perfusion rate as long as autoregulation was preserved. In renin-depleted animals, outer cortical perfusion rate decreased in proportion to pressure reduction. It is concluded that renal autoregulation of blood flow involves two mechanisms: one located in the outer cortical area under the influence of the renin-angiotensin system, the other located in the juxtamedullary compartment and independent of the renin-angiotensin system.

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“…This behavior could also be observed in a series of experiments with normal dogs not reported in this communication and is in agreement with the literature [19,20],…”

Section: Resultssupporting

confidence: 93%

“…Since a reduction of renal perfusion pressure to 100 mm Hg was not accompanied by changes in renal renin pro duction Fojas and Schmid [19] concluded that autoregulation occurs in dependently of the renin-angiotensin system and that this system may be sti mulated only when compensatory mechanisms fail to maintain RBF constant.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Renin on the Intrarenal Distribution of Blood Flow and Autoregulation

Brech¹,

Sigmund²,

Kadatz³

et al. 1974

Nephron

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“…Several studies have suggested that the renin-angiotensin system may serve as a modulator o f autoregulatory responses, as it is known that increased renin release occurs when the R A P is decreased, even within the autoregulatory range [18][19][20]. Such increases in renin could increase angiotensin I and II concentrations within the kidney as well as in the blood [2,5].…”

Section: Discussionmentioning

confidence: 99%

Renal Autoregulatory Efficiency during Angiotensin-Converting Enzyme Inhibition in Dogs on a Low Sodium Diet

Rosivall

Youngblood

Navar

1986

Kidney Blood Press Res

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Autoregulatory efficiency of renal blood flow (RBF) and glomerular filtration rate (GFR) was evaluated in 12 anesthetized dogs that had been maintained on low-sodium diet during control conditions and following infusion of an angiotensin-converting enzyme inhibitor (captopril). Converting enzyme inhibition (CEI) decreased systemic blood pressure by 15.5 ± 3.5%, increased RBF by 36.3 ± 6.5%, and increased GFR by 25.9 ± 10.7%. In response to reductions in renal arterial pressure, RBF was efficiently autoregulated and did not change significantly until the 89- to 75-mm Hg range during the control period and the 74- to 54-mm Hg range during CEI. Overall GFR autoregulatory efficiency was generally well maintained during CEI; however, evaluation of the coupled autoregulatory efficiency of RBF and GFR indicated that during angiotensin blockade, there was a greater incidence of a dissociation between RBF and GFR autoregulatory efficiency. Six of the 12 dogs showed reduced GFR autoregulatory efficiency at renal arterial pressures where RBF was still well maintained. Thus, while the data indicate that blockade of the renin-angiotensin system does not abolish the basic capability of the kidney to autoregulate either RBF or GFR efficiently, more subtle influences on the coupling of RBF and GFR autoregulatory efficiency were observed at the lower level of the autoregulatory range.

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“…Although there has been controversy about the intrarenal formation of angiotensin II, some recent work (14) supports the possibility. Mannitol is known to decrease renin release from hypoperfused kidneys (15,16). In the experiments of Fojas and Schmid (16) in dogs, mannitol reduced renin production by the kidney significantly at 50 mm Hg arterial pressure.…”

Section: Introductionmentioning

confidence: 99%

“…Mannitol is known to decrease renin release from hypoperfused kidneys (15,16). In the experiments of Fojas and Schmid (16) in dogs, mannitol reduced renin production by the kidney significantly at 50 mm Hg arterial pressure. If mannitol acts through alterations in the renin-angiotensin system in our experiments, its effect must be exerted at an extratubular locus, since it restarted GF in nephrons in which it had already stopped.…”

Section: Introductionmentioning

confidence: 99%

Restoration and maintenance of glomerular filtration by mannitol during hypoperfusion of the kidney

Morris¹,

Alexander²,

Bruns³

et al. 1972

J. Clin. Invest.

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A B S T R A C T Glomerular filtration (GF) during progressive reduction of renal perfusion pressure by aortic clamping was studied in hydropenic rats and in rats infused with isotonic saline, hypertonic saline, or mannitol. As judged by visual observation of Lissamine green movements in superficial nephrons, GF was absent in hydropenic or saline-loaded rats at 40 mm Hg aortic pressure, but continued in some nephrons of all rats infused with mannitol and of some rats infused with hypertonic saline. Urine flow persisted only in rats infused with mannitol. By use of the qualitative Hanssen technique, it was found that all glomeruli in superficial and deep portions of the cortex were perfused at 40 mm Hg in all groups of rats. By the same method, GF continued in 1% of nephrons in hydropenic rats, 12% of nephrons in isotonic saline-loaded rats, and 78% of nephrons in rats infused with mannitol. By means of a quantitative Hanssen technique, GF was 5.8 nl/min per nephron in mannitol-infused rats and not measurable (<0.5 nl) in hydropenic rats. Superficial and deep nephrons were similar in both qualitative and quantitative studies. Although urine flow did not persist in rats infused with hypertonic saline, GF was detected in four of seven studies by the Hanssen method (mean, 9.1 nl/min per nephron). In additional experiments, mannitol infused after perfusion pressure had already been-lowered to 40 mm Hg in hydropenic rats reestablished urine flow and GF (mean, 9.8 nl/min). Furosemide, isotonic and hypertonic saline did not restart urine flow; however, GF (Lissamine green) was restarted by hypertonic saline. We conclude that mannitol can maintain or reestablish by an extratubular mechanism GF which otherwise would not occur during renal hypoperfusion. Hypertonic saline has a similar effect on GF in some cases, but urine

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Renin release, renal autoregulation, and sodium excretion in the dog

Cited by 33 publications

References 0 publications

The Influence of Renin on the Intrarenal Distribution of Blood Flow and Autoregulation

The Influence of Renin on the Intrarenal Distribution of Blood Flow and Autoregulation

Renal Autoregulatory Efficiency during Angiotensin-Converting Enzyme Inhibition in Dogs on a Low Sodium Diet

Restoration and maintenance of glomerular filtration by mannitol during hypoperfusion of the kidney

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