Green tea (Camellia sinensis) has anti-oxidant and anti-inflammatory properties and may enhance wound healing process. The present study, therefore, was aimed to examine the effect of green tea ethanolic extract on wound healing process. For this experimental study, 36 healthy male Wistar rats were randomly designated to three groups of A, B, and C which, respectively treated with, Vaseline + 0.6% green tea extract, Vaseline and normal saline for 21 days. Wounds' length and area were measured by caliper every other day and specimens were taken at 3rd, 12th, and 21st day for microscopical examinations. Data were analyzed by SPSS 16 using survival analysis (Breslow test), repeated measured ANOVA, one-way ANOVA and Mann-Whitney. P < 0.05 was considered as statistically significant. The mean healing duration of surgical wounds in groups A and B was 14.66 and 20.66 (P = 0.018), respectively. Decrease in healing duration in the group A was significantly higher within the first two weeks compared with control groups (P = 0.05). Microscopic examinations also indicated a significant difference in wound healing process between groups A and C throughout the whole study duration as well as groups A and B during the 3rd week of the study (P < 0.05). Green tea extract could help wound healing process, probably effective on surgical wounds healing.
Aim: Adhesion formation is the greatest complication in abdominal surgery. Silybum marianum (S. marianum) extract contains phenolic compounds whit antioxidant activities, thus could reduce adhesion formation. The aim of the present study was to examine its effect on intraabdominal adhesion. Patients and Methods: Thirty male Wistar rats were randomly divided into three groups. Groups A and B received 1 per cent and 5 per cent concentrations of the S. marianum extract, and group C (control group) received distilled water. After anaesthesia was administered, the abdominal wall was opened and three shallow, longitudinal and transverse incisions (2 cm in length) were made on the right wall of the abdomen. A 2 × 2 cm piece was removed from the peritoneal surface on the left side of the abdominal wall; 3 mL of S. marianum extract or distilled water was then administered into the abdominal cavity. Adhesion degrees were determined according to the Canbaz scale. Histopathological examination was also determined according to the severity of fibrosis and inflammation. Data analysis was performed using SPSS version16. Results: There was significant difference in the adhesion formation between the groups (P = 0.023). The adhesion degree in groups A and B were significantly lower than that of the control (P < 0.05). In the histopathological examination, significant differences were observed between the control and extract-treated groups in term of fibrosis and inflammation (P < 0.05). Conclusion: S. marianum extract has preventive effects on post-laparotomy intraabdominal adhesion. Therefore, through further clinical studies, S. marianum extract and its derived compounds might be used in humans for the treatment of these complications.
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