A simple and mild method for the conversion of varieties of a a,b b-unsaturated carboxylic acids to the corresponding bromoalkenes using diacetoxyiodobenzene (IBD) in combination with tetraethyl-ammonium bromide (TEAB) at room temperature is discussed. Advantages of this system are short reaction time, easy work up and gave good to excellent yields.
ARTICLE INFO ABSTRACTProtein kinases have important role in cell proliferation & differentiation of cell. They involved in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli, mediator of signaling cascade. Tyrosine kinases are enzymes that selectively phosphorylates tyrosine residue in different substrates. Over expression of these tyrosine kinases receptor cause development of human cancer. So lot of work is done to understand role of tyrosine kinases in the pathophysiology of cancer. Defective regulation of growth processes plays a role in the genesis and progression of most type of cancer. Oncogenic activation of tyrosine kinase due to mutation, autocrine-paracrine stimulation in cancer cells can be blocked by selective tyrosine kinase inhibitors and thus considered as a promising approach for treatment of cancer. This review describes the role of growth factors in development of cancer & the role of TK inhibitors or growth blockers on treating cancer. This review article describes the mechanism of action, structures, and side effects of potent protein kinase inhibitors.
Meliaceae is a family of 50 genera with 1400 species that are predominantly found in tropical parts of the third world. Because of its timber and calorific value, members of this family are commercially valuable. Mahogany is a Meliaceae family exotic plant that includes three species: Swietenia macrophylla king, S mahogany L. Jacq., and S. humulis Zucc. Mahogany's distribution in India is limited to the Western and Eastern Ghats. This genus is predominantly found in the humid zone of the New World and the Amazon region of South America. The purpose of this review article is to look at its botanical description, geographical distribution, ecological range, cultivation and collection methods, wood characteristics, wood uses, therapeutic uses, seed cultivation and propagation practices, and wood characteristics, wood uses, and therapeutic uses.
Mahogany is a Meliaceae family exotic plant that includes three species: Swietenia macrophylla king, S mahogany L. Jacq., and S. humulis Zucc. This genus is predominantly found in the humid zone of the New World and the Amazon region of South America. The purpose of this review article is to look at its taxonomical classification, vernacular names, pharmacological activities and its phytochemistry. Scientific studies have found that the crude extract from S. macrophylla seeds has antibacterial, anti-malaria, anti-hepatitis, anti-diarrheal, antioxidant, anti-diabetic, anti-inflammatory, anti-mutagenic, antinociceptive, and anticancer properties. Phytochemical investigations have shown that limonoids and their derivatives are the major constituents of Swietenia macrophylla.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.