An efficient synthesis of a novel series of twelve substituted 2-amino-3-cyano-4H-pyran derivatives was achieved by a one-pot three-component cyclocondensation reaction of heteroaryl aldehydes, malononitrile and active methylene compounds catalyzed by iodine in aqueous medium under ultrasound irradiation. In comparison with conventional methods, our protocol is convenient and offers several advantages, such as shorter reaction time, higher yields, milder conditions and environmental friendliness. We have herein successfully demonstrated the synergistic outcome of multi-component reaction (MCR) and sonication to offer a facile route for the design of these derivatives.

Multicomponent reactions (MCRs) have emerged as key green tool in organic synthesis for their methodological simplicity. MCRs have made heterocycle synthesis more versatile. The most crucial molecule among the most often used heterocycles is pyridine, which is widely used in biological, industrial, and pharmaceutical sectors. In light of this, our mini-review highlights the literature on substituted pyridine synthesis published from the year 2016 to early 2022 via multicomponent approach.

An atom efficient protocol via a one-pot four-component cyclocondensation reaction catalyzed by copper(i) iodide in aqueous medium under ultrasonic irradiation has been developed for the synthesis of novel polysubstituted 1,4-dihydropyridines.

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An efficient, environmentally benign and inexpensive route to the synthesis of a series of novel substituted pyrazol-ylpyrazolone methanes has been developed via a one-pot pseudo five-component cyclocondensation of aromatic aldehydes, ethyl acetoacetate and phenyl hydrazine catalyzed by FeSO 4 ·7H 2 O in aqueous medium. The single-crystal X-ray diffraction was obtained for two of the derivatives. Our approach, in comparison with other reported methods is noteworthy, as it offers several advantages, such as shorter reaction time, higher yields, mild conditions, is expeditious and clean. We have herein successfully demonstrated a perfect synergy for eco-compatible organic synthesis.[a] S.

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