Multicomponent reactions (MCRs) have emerged as key green tool in organic synthesis for their methodological simplicity. MCRs have made heterocycle synthesis more versatile. The most crucial molecule among the most often used heterocycles is pyridine, which is widely used in biological, industrial, and pharmaceutical sectors. In light of this, our mini-review highlights the literature on substituted pyridine synthesis published from the year 2016 to early 2022 via multicomponent approach.

Carbonylation of (hetero)­aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd–Co­(CO)4 bimetallic catalysis is accomplished. The use of Co2(CO)8 as a solid CO­(g) source enhanced reaction rates observed when compared to CO­(g), and excellent yields highlight the versatility of the developed protocol. A wide range of electronically and sterically demanding heterocyclic amines and (hetero)­aryl iodides/bromides employed for this study resulted in excellent yields of amino carbonylated products. The developed methodology was further extended to synthesize Trypanosome brucie and luciferase inhibitors.

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Contents:1General Experimental Details 1 2 General Procedure for the synthesis of o-ureidobenzonitriles (3a-3t) 2 3 Characterization details of the synthesized Products 3 -13 4 1 H-NMR, 13 C-NMR and HRMS Spectra 14 -46 5 Crystal analysis data 47-49