An efficient synthesis of a novel series of twelve substituted 2-amino-3-cyano-4H-pyran derivatives was achieved by a one-pot three-component cyclocondensation reaction of heteroaryl aldehydes, malononitrile and active methylene compounds catalyzed by iodine in aqueous medium under ultrasound irradiation. In comparison with conventional methods, our protocol is convenient and offers several advantages, such as shorter reaction time, higher yields, milder conditions and environmental friendliness. We have herein successfully demonstrated the synergistic outcome of multi-component reaction (MCR) and sonication to offer a facile route for the design of these derivatives.

An atom efficient protocol via a one-pot four-component cyclocondensation reaction catalyzed by copper(i) iodide in aqueous medium under ultrasonic irradiation has been developed for the synthesis of novel polysubstituted 1,4-dihydropyridines.

a b s t r a c tA simple, facile and an efficient procedure for the N-sulfonylation of amines, imides, amides and anilides using p-TsCl in the presence of atomized sodium in a mixture of EtOH-THF under sonic condition is developed. The method is rapid, mild and inexpensive; yields are high and the reactions go to completion within 2-8 min.

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A series of novel polysubstituted 1,4‐dihydropyridines is synthesized via a one‐pot four‐component cyclocondensation reaction of aromatic aldehydes, malononitrile, acetylenedicarboxylates, and arylamines catalyzed by copper(I) iodide in aqueous medium under ultrasound irradiation.