A series of new oxopyrimidine were prepared by cyclocondensation route with various substituted chalcones in presence of alcoholic solution of potassium hydroxide at reflux temperature. The synthesized oxopyrimidine derivatives were characterized by means of their IR,1H NMR, mass spectral data and elemental analysis. The synthesized oxopyrimidines derivatives were evaluated for antibacterial and antifungal activities, some of them were found to possess significant activity.
Benzimidazole is the heterocyclic compound formed from benzene and imidazole ring containing nitrogen, oxygen sulphur and its derivatives are of wide interest because of their diverse biological activity. A new method for synthesis of 2-(substituted phenyl)-1Hbenzo[d]imidazole (3a-k) are developed by using simple method, green approach in good yields. We have synthesized 33 molecules in gram scale. This method is extremely useful for the synthesis of benzimidazole derivatives in excellent yields.
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