Synthesis and Biological Activity of Some 3,4‐Dihydro‐4‐(4‐substituted aryl)‐6‐(naptho[2,1‐b]furan‐2‐yl pyrimidine‐2(1H)‐one Derivatives

Abstract

A series of new oxopyrimidine were prepared by cyclocondensation route with various substituted chalcones in presence of alcoholic solution of potassium hydroxide at reflux temperature. The synthesized oxopyrimidine derivatives were characterized by means of their IR,1H NMR, mass spectral data and elemental analysis. The synthesized oxopyrimidines derivatives were evaluated for antibacterial and antifungal activities, some of them were found to possess significant activity.

Chalcones as Versatile Synthons for the Synthesis of 5- and 6-membered Nitrogen Heterocycles

“…The reaction with substituted thioureas using basic cata- lysts afforded 3,4-dihydropyrimidin-2(1H)-thiones, in moderate yields [429]. Other 3,4-dihydropyrimidin-2(1H)-(thi)ones can be synthetized through the condensation of chalcone-type compounds with (thio)urea under the effect of KOH in refluxing ethanol (Scheme 61) [120,430]. Using the same conditions, functionalized 5,6-dihydropyrimidin-2(1H)-(thi)ones bearing thiophene [220] and benzofuran [118] moieties were prepared.…”

8‐Nitronaphthofuran Fused Urea Derivatives as Potential Antimicrobial Agents: Synthesis, Characterization and Pharmacological Studies

“…In the last 3–4 decades, we observe the development of heterocyclic structures to treat various deadly diseases caused by bacterial, fungal and viral infections [1–5] . Among them, the drugs designed on the incorporation of furan, [6,7] benzofuran [8,9] and naphthofuran [10,11] nucleus exhibit excellent antimicrobial, antiviral, antioxidant, anthelmintic and anti‐inflammatory activities. Close observation of the literature on the synthesis of urea derivatives provided wide applications in the field of agrochemicals, [12,13] cellulose fibres, [14] corrosion inhibitors [15] .…”

One‐potandtwo‐potmethods for chalcone derived pyrimidines synthesis and applications

“…[13] moiety due to their potential and applications in electrochromic, solvatochromic, optical, photochromic, [14] anti-corrosive, [15] chemosensor, [16] optoelectronics or organic light-emitting diodes, [17] and photoproduct of DNA. [18] In therapeutic industry, pyrimidine derivatives have also been reported to have a broad spectrum of biological properties, that is, anticancer, [19][20][21][22][23][24][25][26][27][28][29][30] antihistamine, [31,32] antinociceptive, [33] antilipase, [34] antifilarial, [35] antiparasitic, [36] antioxidant, [37,38] antituberculosis, [39,40] antihypertensive, [41] antimicrobial, [42][43][44][45][46][47] anticonvulsant, [48,49] antiallergic, [50,51] antipyretic, [52] anti-inflammatory. [53,54] antifungal, [55,56] antiviral, [57]…”