A semi-interpenetrating polymer network (IPN) comprising gelatin and poly(2-hydroxyethyl methacrylate-co-acrylamide) was prepared and characterized by FTIR, environmental scanning electron microscopy (ESEM) and differential scanning calorimetry (DSC) techniques. The water sorption potential of the prepared semi-IPNs was investigated for varying chemical architecture of the IPN, and experimental conditions such as pH, temperature and ionic strength of the swelling media. The semi-IPNs were also judged for in vitro blood compatibility by performing blood clot, percent hemolysis, protein adsorption and platelet adhesion tests.
pH responsive smart biomaterials of gelatin and poly(2-hydroxyethyl methacrylate-co-acrylic acid) were synthesized by redox polymerization and characterized by FTIR, Environmental Scanning Electron Microscopy (ESEM). The prepared environmental responsive biomaterials containing polyelectrolyte segments were assessed for their water sorption potential under varying experimental conditions. The diffusion mechanism of transport of water molecules arising due to solvent-polymer interaction was also analysed to predict the behaviour of continuously relaxing macromolecular chains. The in vitro blood compatibility of the prepared polymeric hydrophilic materials was evaluated by methods such as blood clot formation, platelet adhesion, percent haemolysis and protein-adsorption study on the surface of the prepared biomaterials.
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