Evaluation of water sorption property and in vitro blood compatibility of poly(2-hydroxyethyl methacrylate) (PHEMA) based semi interpenetrating polymer networks (IPNs)

Abstract

pH responsive smart biomaterials of gelatin and poly(2-hydroxyethyl methacrylate-co-acrylic acid) were synthesized by redox polymerization and characterized by FTIR, Environmental Scanning Electron Microscopy (ESEM). The prepared environmental responsive biomaterials containing polyelectrolyte segments were assessed for their water sorption potential under varying experimental conditions. The diffusion mechanism of transport of water molecules arising due to solvent-polymer interaction was also analysed to predict the behaviour of continuously relaxing macromolecular chains. The in vitro blood compatibility of the prepared polymeric hydrophilic materials was evaluated by methods such as blood clot formation, platelet adhesion, percent haemolysis and protein-adsorption study on the surface of the prepared biomaterials.

Synthesis and Characterization of Chemically Cross-Linked Acrylic Acid/Gelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release

“…The interpenetrating networks (IPNs) and copolymers containing acrylic acid have also been reported to exhibit thermoresponsive, electroresponsive, and pH-responsive behavior [9]. Poly(acrylic acid) is well recognized for its polyanionic nature and has been extensively employed in designing pH-responsive macromolecular architectures mainly used in targeted drug delivery [10]. The pKa value of poly(acrylic acid) is between 4.5 and 5.0, and PAA hydrogels swell significantly at the physiological pH of 7.4 due to ionization of the anionic carboxylic acid groups [11].…”

Initiated and oxidative chemical vapor deposition: a scalable method for conformal and functional polymer films on real substrates

“…26 Another biocompatibility strategy is to use thin hydrogel films to reduce the degree of non-specific protein adhesion. Two such hydrogels are PHEMA and poly(vinyl pyrrolidone) (PVP); both have been used for biological and biomedical applications [27][28][29][30] and their biocompatibility, including resistance to non-specific protein adhesion, [31][32][33][34][35] has been studied. Both linear and crosslinked versions of these polymers have been deposited via iCVD.…”

Synthesis and Characterization of Acrylamide/Acrylic Acid Co-Polymers and Glutaraldehyde Crosslinked pH-Sensitive Hydrogels

“…Temperature-sensitive and pH-responsive behavior has also been displayed by the copolymers AA and the interpenetrating networks (IPNs) [ 14 ]. Also, pH-sensitive macromolecular structures designed by the poly(AA) (PAA) have been explored for use in site-specific drug delivery systems [ 15 ]. Owing to the ionization of the carboxylic acid (CA) functionalities, the PAA based hydrogels swell considerably at pH 7.4 since its pKa value ranges from 4.5–5 [ 16 ].…”