This prospective longitudinal cohort study was to assess the 10-yr hip fracture incidence and mortality trend of person ≥50 yr of age between 2002 and 2011 of eight hospitals in Jeju Island. Sex-specific incidence rate (per 100,000 person-years) were calculated based on that estimated for the population in the United States in 2008. Poisson and logistic regressions were used to examine trends in incidence and mortality. There was a 101% increase in the number of hip fractures from 151 in 2002 to 304 in 2011. The crude incidence of hip fractures in the Jeju population ≥50 yr of age increased from 126.6/100,000 to 183.7/100,000. The fracture incidence in the population standardized to the 2008 population in the United States increased from 100.6/100,000 for men and 194.4/100,000 for women in 2002 to 114.2/100,000 for men and 278.4/100,000 for women in 2011. The annual increasing incidence rate of hip fracture was 4.3% (5.3% in women and 2.2% in men). Poisson regression did not show significant trends in the mortality rates for all age groups or for both genders. The total number of hip fractures increased two-fold and the incidence rate of hip fractures increased markedly during the 10-yr study period.Graphical Abstract
This prospective cohort study was performed to estimate the morbidity and mortality with 790 patients over 50-yr of age that sustained a femoral neck or intertrochanteric fracture from 2002 to 2006, followed-up for a mean of 6 yr (range, 4 to 9 yr). Crude and annual standardized mortality ratios (SMRs) were calculated; and mortalities in the cohort and the age and sex matched general population were compared. The risk factors on mortality and activities pre- and post-injury were assessed. Accumulated mortality was 16.7% (132 patients) at 1 yr, 45.8% (337 patients) at 5 yr, and 60% (372 patients) at 8 yr. SMR at 5 yr post-injury was 1.3 times that of the general population. Multivariate analysis demonstrated that age (OR, 1.074; 95% CI, 1.050-1.097; P<0.001), woman (OR, 1.893; 95% CI, 1.207-2.968; P=0.005), and medical comorbidity (OR, 1.334; 95% CI, 1.167-1.524 P<0.001) were independently associated with mortality after hip fracture. Only 59 of the 150 patients (39.3%) who were able to ambulate normally outdoors at preinjury retained this ability at final follow-up. Patients with a hip fracture exhibits higher mortality at up to 5 yr than general population. Age and a preinjury comorbidity are associated with mortality.
Our results demonstrate for the first time that PPARγ agonists may have beneficial effects on the migration and invasion of RA-FLS via the downregulation of Cyr61. Therefore, PPARγ agonists could be potential treatment targets for RA.
[Purpose] The aim of this study was to evaluate the efficacy of mechanical massage via
Endermologie® after total knee arthroplasty in reducing edema and pain and
improving knee range of motion, in the early postoperative period. [Subjects and Methods]
Eighteen patients with knee edema following total knee arthroplasty were randomly assigned
to the intervention group (n=8) or the control group (n=10). The intervention group
received mechanical massage therapy using Endermologie® and the control group
received conventional physical therapy for 20 minutes a day, 5 times a week from the
seventh day postsurgery. Clinical assessments included active knee flexion and extension
range of motion, knee pain using a numeric rating scale, the operated limb circumference,
the soft tissue cross-sectional area using ultrasonography, the extracelluar fluid volume,
and single frequency bioimpedance analysis at 5 kHz using bioelectrical impedance
spectroscopy. [Results] Both groups showed significant reduction in edema and pain, and
improvement in active knee flexion at the end of treatment. There were no significant
inter-group differences before or after treatment. [Conclusion] Mechanical massage could
be an alternative way of managing knee edema after total knee arthroplasty in early
postoperative recovery.
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