Plants are promising sources of new bioactive compounds. The aim of this study was to investigate the cytotoxic potential of nine plants found in Brazil. The species studied were: Annona pickelii Diels (Annonaceae), Annona salzmannii A. DC. (Annonaceae), Guatteria blepharophylla Mart. (Annonaceae), Guatteria hispida (R. E. Fr.) Erkens & Maas (Annonaceae), Hancornia speciosa Gomes (Apocynaceae), Jatropha curcas L. (Euphorbiaceae), Kielmeyera rugosa Choisy (Clusiaceae), Lippia gracilis Schauer (Verbenaceae), and Hyptis calida Mart. Ex Benth (Lamiaceae). Different types of extractions from several parts of plants resulted in 43 extracts. Their cytotoxicity was tested against HCT-8 (colon carcinoma), MDA-MB-435 (melanoma), SF-295 (glioblastoma), and HL-60 (promielocitic leukemia) human tumor cell lines, using the thiazolyl blue test (MTT) assay. The active extracts were those obtained from G. blepharophylla, G. hispida, J. curcas, K. rugosa, and L. gracilis. In addition, seven compounds isolated from the active extracts were tested; among them, β-pinene found in G. hispida and one coumarin isolated from K. rugora showed weak cytotoxic activity. In summary, this manuscript contributes to the understanding of the potentialities of Brazilian plants as sources of new anticancer drugs.
RESUMoIntrodução: O perfil antropométrico e o consumo alimentar exercem grande influência no desempenho esportivo; entretanto, essas informações sobre tenistas brasileiros ainda são escassas. Objetivo: Descrever e comparar o consumo alimentar e o perfil antropométrico de tenistas amadores (AM) e profissionais (PRO). Métodos: Foram avaliados 24 tenistas, com a seguinte distribuição: profissionais (PRO; n = 9) e amadores (AM; n = 15). Os atletas foram avaliados quanto a variáveis antropométricas (peso, estatura, circunferências e dobras cutâneas) e a composição corporal foi estimada por três diferentes protocolos. As dietas foram avaliadas a partir de três diários alimentares. Resultados: Não houve diferença significativa no perfil antropométrico dos atletas PRO em relação aos AM (peso: 69,5 ± 9,8kg e 66,0 ± 5,0kg; estatura: 177,9 ± 4,3cm e 175,6 ± 2,7cm, IMC: 23,5 ± 1,4kg/m 2 e 22,6 ± 0,8kg/m 2 e gordura corporal: 13,0 ± 5,5% e 13,7 ± 2,4%, respectivamente). Observou-se significativo déficit energético entre a estimativa da necessidade energética e a ingestão energética relatada. O consumo de carboidratos apresentou-se no limite mínimo sugerido (AM: 6,3 ± 0,5g/kg/dia e PRO: 6,5 ± 0,7g/kg/dia), enquanto a ingestão de proteínas mostrou-se superior às recomendações disponíveis na literatura (AM: 2,4 ± 0,2g/kg/dia e PRO: 2,3 ± 0,3g/kg/dia). Com relação aos minerais, a principal preocupação foi a baixa ingestão de cálcio (AM: 798,1 ± 786,3mg/dia e PRO: 766,9 ± 602,4mg/dia). Conclusão: Não foram observadas diferenças significativas no perfil antropométrico e no consumo alimentar entre os atletas AM e PRO. Os desvios observados no consumo alimentar reforçam a necessidade de orientação/planejamento nutricional, a fim de atender às demandas específicas da modalidade, visando maximizar o desempenho.Palavras-chave: tênis, dieta, perfil antropométrico. aBStRaCtThe anthropometric profile and food intake play a key role in sports performance; however, there is little information available regarding Brazilian tennis players. Aim: the present study aimed to evaluate the food intake and the anthropometric profile of professional and amateur tennis players. Methods: twenty-four tennis players were distributed in two groups: professionals (PRO; n = 9) and amateurs (AM; n = 15). The athletes were evaluated on their anthropometric measurements (body weight, height, circumferences and skin folders). Body fat was estimated from three different equations. Food intake was determined by a 3-day food diary. Results: there were no significant differences from anthropometric profile between PRO and AM (body weight: 69.5 ± 9.8 kg and 66.0 ± 5.0 kg; height: 177.9 ± 4.3 cm and 175.6 ± 2.7 cm, BMI: 23.5 ± 1.4 kg/m 2 and 22.6 ± 0.8 kg/m 2 and body fat: 13.0 ± 5.5% and 13.7 ± 2.4%, respectively). Significant difference between the energy expenditure and estimation and reported energy intake was observed. Both groups showed low carbohydrate (AM: 6.3 ± 0.5 g/kg/day and PRO: 6.5 ± 0.7 g/kg/day) and high protein intake AM: 2.4 ± 0.2 g/kg/day and PRO: ...
As humans age, their immune system undergoes modifications, including a low-grade inflammatory status called inflammaging. These changes are associated with a loss of physical and immune resilience, amplifying the risk of being malnourished and frail. Under the COVID-19 scenario, inflammaging increases the susceptibility to poor prognostics. We aimed to bring the current concepts of inflammaging and its relationship with frailty and COVID-19 prognostic; highlight the importance of evaluating the nutritional risk together with frailty aiming to monitor older adults in COVID-19 scenario; explore some compounds with potential to modulate inflammaging in perspective to manage the COVID-19 infection. Substances such as probiotics and senolytics can help reduce the high inflammatory status. Also, the periodic evaluation of nutrition risk and frailty will allow interventions, assuring the appropriate care.
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