The effect of the non-selective 5-HT2C receptor agonist trifluoromethyl-phenylpiperazine (TFMPP, 0.75, 1.5 and 3.0 microg) and the preferential 5-HT2C agonist 6-chloro-2(1-piperazinyl)pyrazine (MK-212, 0.1, 0.3 and 1.0 microg) microinjected into the ventral or dorsal hippocampus was investigated in anxiety measures of rats exposed to the elevated plus-maze test. Ventral hippocampal (VH) microinjections of the 0.75 or 1.5 microg doses of TFMPP reduced open-arm exploration without affecting the number of closed-arm entries, indicating a selective anxiogenic profile. The highest dose (3.0 microg) reduced open- and closed-arm entries, suggesting interference in locomotor activity. The 0.1 microg dose of MK-212 also caused a selective anxiogenic effect when microinjected into the ventral hippocampus, without disturbing locomotor activity. Microinjections of the two higher doses of MK-212 (0.3 or 1.0 microg) into the ventral hippocampus led to a decrease of exploration in both arms of the maze. In contrast to the anxiogenic effect observed in the VH, neither TFMPP nor MK-212 significantly changed anxiety measures when microinjected into the dorsal hippocampus. These results suggest that activation of 5-HT2C postsynaptic receptors located in the ventral, but not in the dorsal, hippocampus play an important role in anxiety triggered by the elevated plus-maze test.

MK-212 increases anxiety and decreases locomotor activity. The anxiogenic-like profile of 5-HT2 receptor activation is prevented by the blockade of 5-HT2 receptors within the BLA, which does not have an effect by itself upon basal anxiety levels triggered by the EPM.

Morphologic analysis of geographic strains of Musca domestica carried out on natural and laboratory experiments starting with 400 and 800 eggs showed phenotypic variations related with latitude. Females of the natural populations showed clines for several morphological traits of the wing, whereas male flies showed a reduction in the dispersion measures (s2 and CV) of wing width and length. The same reduction was obtained for males, females and total number of flies of the natural populations in dispersion of the number of bristles on the fourth abdominal sternite. A significant negative correlation was observed for the head width of females and for the total number of flies emerged in the laboratory experiments started with 400 eggs. All flies produced by the experiments starting with 800 eggs showed a reduction in variability of dispersion of the bristles on the fourth abdominal sternite in the strains obtained from locations south of the area analyzed. Evolutionary aspects of these correlation coefficients between morphometric traits and latitude are discussed.

Abstract

No abstract

The Brazilian Constitutional definition of health as a social right makes the State the guarantor of this legally protected interest. The federalist system adopted in the 1988 Brazilian Federal Constitution determines that the Federal Government, states, and municipalities share the authority to care for health and the concurrent authority to legislate on health matters. This shared authority is based especially on the model of decentralization of public actions and services in health and the regional disparities across Brazil's territory. As Brazil has confronted the COVID-19 pandemic, this heterogeneity has intensified, allowing the Federative Units to adopt different measures that limit rights and public freedoms, depending on the pandemic's progression in the respective geographic area. The range of autonomy for these government entities was recently reaffirmed by the Brazilian Supreme Court (STF) with its ruling on Direct Unconstitutionality Suit n. 6,341/2020 1. The Supreme Court's ruling reinforced the role of local health authorities and public administrators in the adoption of legislative and administrative measures against COVID-19. Each branch of government in Brazil performs its respective role. Since the COVID-19 public health emergency of national concern was declared by the Ministry of Health 2 , extensive legislation has been produced by the Federal Executive and Legislative Branches (Portal da Legislação. Legislação COVID-19. http://www4.planalto.gov.br/legislacao/portal-legis/legislacao-covid-19, accessed on 16/May/2020), not only in health, but also including economic and tax issues, social security, services provision, and individual rights and guarantees, among others. States and municipalities have also contributed to the creation of a new legal framework. The clash between fundamental rights, the exercise of public freedoms, and respect for restrictive rules and confinement, with the aim of drawing limits between the development of administrative rules, jurisprudence on the protection of (and guaranteed access to) health, and the possibility of exercising individual autonomy have been the object of analysis by the Brazilian academic community 3. This scenario provides the backdrop for the first declaration of a lockdown in Brazil, in the cities of São Luís, São José de Ribamar, Paço do Lumiar, and Raposa, all located in the state of Maranhão, under a court order issued on April 30, 2020. The order responded to a claim filed by the local Public Prosecutor, based on the following factors 4 : total occupation of ICU beds dedicated exclusively to COVID-19 in the state public healthcare network; lack of transparency of this same information in the public networks in the above-mentioned cities; provision for lockdown in the Ministry of Health's

RESUMO:A diabetes mellitus é considerada uma síndrome metabólica que vem ganhando grande importância nos dias atuais. Considera-se que no Brasil haja aproximadamente cinco milhões de pessoas diabéticas e que pelo menos metade delas não possui conhecimento do diagnóstico da doença. Os profissionais da área da saúde vêm se preocupando cada vez mais em relação ao autocuidado de seus pacientes, já que muitas vezes não é incorporado à vida diária e, em consequencia disto, podem adquirir grandes complicações crônicas, já que as doenças crônicas demandam um estável cuidado e ajustamento por parte do paciente. Este autocuidado pode estar relacionado às ações que as pessoas seguem em benefício da sua própria saúde. Este estudo qualitativo teve como objetivo verificar a diferença do autocuidado em pacientes com diabetes tipo 1 e tipo 2. Foram entrevistados quatro sujeitos diagnosticados com a doença, com a idade variando de 21 a 57 anos. A análise do tema possibilitou verificar aspectos como diagnóstico, alimentação, exercício físico, pé diabético, cotidiano, autocuidado, aplicação medicamentosa, exames periódicos e o custo de tratar a doença. O resultado aponta que há diferenças no autocuidado em pacientes tipo 1 e tipo 2 sendo que o cuidado com os pés apareceu mais no tipo 1. Palavras-chave: doença crônica, diabetes tipo 1, diabetes tipo 2, autocuidado ___________________________________________________________________________ DIFFERENCES OF SELF-CARE AMONG PATIENTS WITH DIABETES MELLITUS TYPE 1 AND 2ABSTRACT: It is considered that in Brazil there are approximately five million people with diabetes and at least half of them do not have knowledge of the diagnosis. The health care professionals have been concerned increasingly on self-care of their patients, since it is often not incorporated into the daily life and, in consequence of this, can acquire large chronic complications, as chronic diseases a stable and require careful adjustment by the patient. This self-care may be related to the actions that people follow for the benefit of their own health. This qualitative study therefore aimed to determine the difference self-care in patients with type 1 diabetes and type 2 were interviewed four subjects diagnosed with the disease, with age ranging from 21 to 57 years. The subject of analysis enabled us to verify aspects such as diagnosis, nutrition, exercise, diabetic foot, everyday, self-care, drug application, periodic checks and the cost of treating the disease. The result indicates that there are differences in self-care in patients with type 1  Campus do UniCEUB -Asa Norte -Brasília -DF -CEP 70790-075.

ResumoEstresse é uma reação desencadeada pelo corpo para manter-se em equilí-brio. Quando o estresse é excessivo, podem aparecer sintomas físicos, psicológicos, cognitivos e interpessoais. Esta pesquisa teve por objetivo geral analisar os níveis de estresse de alunos da 3ª série do Ensino Médio. Como objetivos específicos, foram definidos: verificar se há diferença no nível de estresse em função do sexo, dos planos futuros e da decisão do curso que pretende cursar já ter sido feita ou não. Participaram da pesquisa 38 alunos de uma escola pública do Distrito Federal.Para coletar os dados, foi utilizada a Escala de Stress para Adolescentes -ESA. Na análise dos dados, foi utilizado o Teste-t e análise de variância Anova One Way.Após a análise dos dados, verificou-se que 13% dos alunos estavam com nível de estresse elevado. Foi encontrada diferença na comparação entre os sexos feminino e masculino no fator interpessoal. Pesquisas anteriores já haviam encontrado diferença entre os sexos em outras faixas etárias, aplicando outros testes. Os achados são discutidos com base na teoria da área.Palavras-chave: Stress. Estudantes. 3º ano. Ensino médio.