No abstract

A retrospective study of the functional alteration of the urethra following hysterectomy was made in 98 patients. Three groups were identified. Sixty per cent (group A) had stable stress urinary incontinence, 27.8% (group B) had high pressure detrusor instability and 12.2% (group C) had voiding dysfunction. Some of the patients in group A were treated medically and others surgically. Those in group B were treated with oxybutinin and those in group C were treated surgically. The cure rate in group A ranged from 55 to 89%; in group B it was 82% and in group C between 90 and 100%.

The development of biochemical tumor markers has increased the use of antibody-dependent tumor marker assays in gynecologic oncology. Several monoclonal antibodies directed against novel epitopes on tumor-associated antigens have allowed the development of sensitive assays for serum markers. Assays for human chorionic gonadotrophin and TA-4 have been improved. CA 125 has provided a useful first-generation markers. Ovarian cystoadeno-carcinoma-associated antigen and lipid-associated sialic acid have been developed for ovarian cancer, transforming growth factor for squamous cancer, and placenta protein 4 for endometrial and cervical cancer. The most widely applied procedures to identify these markers are immunofluorescent microscopy and immunocytochemical staining. Multiple markers and modalities may be required to increase the sensitivity of tumor detection. CA 15-3 and GCDFP-15 markers have been useful in detecting breast cancer. The application of radionuclide imaging will provide a new field for the diagnosis of gynecologic malignancies.

No abstract

No abstract

No abstract

No abstract

No abstract