Management of Patients with Early-Stage Ovarian Cancer

Farghaly, Samir A.

doi:10.1007/978-1-4614-8271-0_9

Cited by 2 publications

(2 citation statements)

References 95 publications

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“…Hypoxia is one of the fundamental characteristics of solid tumors including ovarian cancer and metastatic colonization usually involves peritoneal metastases of ovarian cancer [ 36 , 37 ]. Thus, targeting hypoxia in cancer therapy has become a promising therapeutic approach to impede peritoneal metastases of ovarian cancer [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment

Liang

Yung

et al. 2021

Cancers

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Emerging evidence indicates that hypoxia plays a critical role in governing the transcoelomic metastasis of ovarian cancer. Hence, targeting hypoxia may be a promising approach to prevent the metastasis of ovarian cancer. Here, we report that BCL2A1, a BCL2 family member, acts as a hypoxia-inducible gene for promoting tumor progression in ovarian cancer peritoneal metastases. We demonstrated that BCL2A1 was induced not only by hypoxia but also other physiological stresses through NF-κB signaling and then was gradually reduced by the ubiquitin-proteasome pathway in ascites-derived ovarian cancer cells. The upregulated BCL2A1 was frequently found in advanced metastatic ovarian cancer cells, suggesting its clinical relevance in ovarian cancer metastatic progression. Functionally, BCL2A1 enhanced the foci formation ability of ovarian cancer cells in a stress-conditioned medium, colony formation in an ex vivo omental tumor model, and tumor dissemination in vivo. Under stress conditions, BCL2A1 accumulated and colocalized with mitochondria to suppress intrinsic cell apoptosis by interacting with the BH3-only subfamily BCL2 members HRK/BAD/BID in ovarian cancer cells. These findings indicate that BCL2A1 is an early response factor that maintains the survival of ovarian cancer cells in the harsh tumor microenvironment.

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Section: Discussionmentioning

confidence: 99%

The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment

Liang

Yung

et al. 2021

Cancers

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“…It has been reported that metastasis of ovarian granulosa tumor to the lung leads to structural changes and dysfunction in the lung tissue [ 15 ]. This giant panda is diagnosed with ovarian cancer [ 16 ]; her death may be due to granulosa cell tumor and theca cell tumor metastasis leading to multiple organs dysfunction or even failure. In summary, clinical biomarkers combined with histopathology can provide a more accurate diagnosis of ovarian cancer metastasis and identification of ovarian cancer types.…”

Section: Discussionmentioning

confidence: 99%

A case of giant panda ovarian cancer diagnosis and histopathology

Gao

Wang

et al. 2018

BMC Vet Res

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BackgroundOvarian cancer is diagnosed clinically by detecting ovarian cancer-related factors and markers. Here, we report a case of giant panda ovarian tumor metastasis with a combination of clinical and histopathological diagnosis.Case presentationHistopathological studies revealed severe lesions and tumor cells in the ovaries, lungs, spleen, kidneys and perianal tissue. Immunohistochemistry staining showed that the ovarian cancer markers B7-H4, CA125, and HE4 were highly expressed in the lungs, kidneys, spleen, ovaries and perianal tissue. Tumor marker tests detected significantly high levels of AFP in serum.ConclusionClinical biomarkers combined with histopathology can provide a more accurate diagnosis of ovarian cancer metastasis and identification of ovarian cancer types than either method alone. The giant panda’s death may be due to granulosa cell tumor and theca cell tumor metastasis causing multiple organ dysfunction or even failure.

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Management of Patients with Early-Stage Ovarian Cancer

Cited by 2 publications

References 95 publications

The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment

The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment

A case of giant panda ovarian cancer diagnosis and histopathology

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