A case of giant panda ovarian cancer diagnosis and histopathology

Gao, Qi; Wang, Chengdong; Li, Desheng; Zhang, Hemin; Linhua, Deng; Li, Caiwu; Chen, Zhengli

doi:10.1186/s12917-018-1630-x

Cited by 8 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high mitotic count is also an important histological graduation factor in breast neoplasms and soft tissue sarcomas in dogs (Cassali et al, ; Dennis et al, ); however, in the GCT, a high mitotic count in female dogs (Patnaik & Greenlee, ), in cows (Mimoune et al, ), in panda (Gao et al, ) and in women (Inoue et al, ; Le Frère‐Belda, ) has not been observed. This data agree with the results obtained, since most of the tumour samples presented a low mitotic count.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Histopathological findings in the early diagnosis of granulosa cell tumour in bitches

Matos

Leite

Consalter

et al. 2019

Reprod Domestic Animals

View full text Add to dashboard Cite

Contents Granulosa cell tumour (GCT) is a majorly observed ovarian tumour in female dogs. It is essential to diagnose GCT in its initial phase before any symptoms occur, as histological and physiological differences may be observed based on the evolution of this neoplasia. This study aimed to analyse the anatomic histopathology of GCT in its initial stage, with findings of ovaries not yet with the suspicion of neoplasms in the Canis familiaris. A sample including 55 ovaries presented GCT in 40 female dogs. The histopathological analysis was performed considering the intensity of pleomorphism, vascularization and inflammatory infiltrate. Furthermore, we evaluated the mitoses count in 10 fields using 40× magnification. Out of the 40 animals evaluated, 62.5% (25/40) presented the tumour in only one ovary. The Call‐Exner corpuscle was present in 65% (26/40) of the cases. The follicular histological pattern was present in 52.5% (21/40) of the animals. The presence of the Call‐Exner bodies and the degree of tumour cell pleomorphism (p = 0.033) were associated. Moreover, the degree of vascularization and the intensity of the inflammatory infiltrate were also related (p = 0.001). In addition, there was a positive relationship between the increase in pleomorphism and the mean age of the animals (p = 0.044). This study confirmed that the appearance of this tumour may precede any clinical symptomatology. In this study, the most frequent histopathological pattern was the follicular. The characteristics of the granulosa cell tumour diagnosed early were poorly pleomorphic cells, low mitotic index and presence of Call‐Exner body.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Regarding the degree of malignancy, the low aggressiveness in bitches was observed when compared to cats (Moulton, 1990). Metastasis has been reported in other animals such as cow, panda and snake (Gao et al, 2018;Mimoune, Kaidi, Belarbi, Kaddour, & Azzouz, 2017;Pirson, Geerinckx, Bosseler, Simard, & Hellebuyck, 2018).…”

mentioning

confidence: 99%

Histopathological findings in the early diagnosis of granulosa cell tumour in bitches

Matos

Leite

Consalter

et al. 2019

Reprod Domestic Animals

View full text Add to dashboard Cite

show abstract

“…Similarly, ursids can develop a wide variety of cancers, ranging from mammary tumors in brown bears ( Ursus arctos ) to hepatic carcinomas in polar bears ( Ursus maritimus ). The panda and the sloths, which are mainly herbivorous, are not exempted [ 119 , 120 ].…”

Section: Non-model and Alternative Model Vertebrate Species Susceptib...mentioning

confidence: 99%

Beyond the Lab: What We Can Learn about Cancer from Wild and Domestic Animals

Schraverus

Larondelle

Page

2022

Cancers

View full text Add to dashboard Cite

Cancer research has benefited immensely from the use of animal models. Several genetic tools accessible in rodent models have provided valuable insight into cellular and molecular mechanisms linked to cancer development or metastasis and various lines are available. However, at the same time, it is important to accompany these findings with those from alternative or non-model animals to offer new perspectives into the understanding of tumor development, prevention, and treatment. In this review, we first discuss animals characterized by little or no tumor development. Cancer incidence in small animals, such as the naked mole rat, blind mole rat and bats have been reported as almost negligible and tumor development may be inhibited by increased defense and repair mechanisms, altered cell cycle signaling and reduced rates of cell migration to avoid tumor microenvironments. On the other end of the size spectrum, large animals such as elephants and whales also appear to have low overall cancer rates, possibly due to gene replicates that are involved in apoptosis and therefore can inhibit uncontrolled cell cycle progression. While it is important to determine the mechanisms that lead to cancer protection in these animals, we can also take advantage of other animals that are highly susceptible to cancer, especially those which develop tumors similar to humans, such as carnivores or poultry. The use of such animals does not require the transplantation of malignant cancer cells or use of oncogenic substances as they spontaneously develop tumors of similar presentation and pathophysiology to those found in humans. For example, some tumor suppressor genes are highly conserved between humans and domestic species, and various tumors develop in similar ways or because of a common environment. These animals are therefore of great interest for broadening perspectives and techniques and for gathering information on the tumor mechanisms of certain types of cancer. Here we present a detailed review of alternative and/or non-model vertebrates, that can be used at different levels of cancer research to open new perspectives and fields of action.

show abstract

“…In an Eurasian brown bear ( Ursus arctos arctos ) with ovarian cancer, metastases were observed in the regional lymph nodes and brain, with immunohistochemistry showing strong positivity for cytokeratin AE1/AE3 [21], an antigen which is expressed by more than 90% of human ovarian carcinomas [75]. In a recent case report of a giant panda ( Ailuropoda melanoleuca ) with ovarian cancer, histopathological studies revealed multiple lesions in the lungs, kidneys, perianal tissue and spleen at necropsy, that stained positive by immunohistochemistry for B7-H4, CA125, and HE4, as well as the presence of significantly high serum levels of the tumour antigen AFP [23]. In humans, the combination of HE4 and CA125 expression is currently used in the clinic for accurate diagnosis of malignant ovarian tumours [76], and AFP is used in the clinic as a tumour marker.…”

Section: Occurrences Of Spontaneous Metastasis In Non-laboratory Animalsmentioning

confidence: 99%

Metastasis in the wild: investigating metastasis in non-laboratory animals

Abu-Helil

Weyden

2019

Clin Exp Metastasis

View full text Add to dashboard Cite

Humans are not the only species to spontaneously develop metastatic cancer as cases of metastasis have been reported in a wide range of animals, including dinosaurs. Mouse models have been an invaluable tool in experimental and clinical metastasis research, with the use of genetically-engineered mouse models that spontaneously develop metastasis or ectopic/ orthotopic transplantation of tumour cells to wildtype or immunodeficient mice being responsible for many key advances in our understanding of metastasis. However, are there other species that can also be relevant models? Similarities to humans in terms of environmental exposures, lifespan , genetics, histopathology and available therapeutics are all factors that can be considered when looking at species other than the laboratory mouse. This review will explore the occurrence of metastasis in multiple species from a variety of domestic, captive and free-living veterinary cases to assist in identifying potential alternative experimental and clinical research models relevant to humans.

show abstract

A case of giant panda ovarian cancer diagnosis and histopathology

Cited by 8 publications

References 13 publications

Histopathological findings in the early diagnosis of granulosa cell tumour in bitches

Histopathological findings in the early diagnosis of granulosa cell tumour in bitches

Beyond the Lab: What We Can Learn about Cancer from Wild and Domestic Animals

Metastasis in the wild: investigating metastasis in non-laboratory animals

Contact Info

Product

Resources

About