Immunotherapy for Precancerous Lesions of the Uterine Cervix

Farghaly, Samir A.

doi:10.1007/978-3-030-02701-8_7

Cited by 2 publications

(18 citation statements)

References 205 publications

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“…It is lined by multilayered nonkeratinized squamous epithelium comprising basal, parabasal, intermediate, and superficial cells with abundant intracytoplasmic glycogen. The 2 types of epithelia meet at the squamocolumnar junction 4,5…”

Section: The Cervix—histoanatomic Considerations Of Diagnostic Import...mentioning

confidence: 99%

“…2A–D). The exact origin of the reserve cells is not known, but they are probably derived from a specific embryonic cell population within the columnar epithelium 4–6…”

Section: The Cervix—histoanatomic Considerations Of Diagnostic Import...mentioning

confidence: 99%

“…Furthermore, the squamocolumnar junction recedes after menopause for variable distances into the endocervix (Fig. 1) and is no longer visible during a colposcopic examination 4–7…”

Section: The Cervix—histoanatomic Considerations Of Diagnostic Import...mentioning

confidence: 99%

“…Sexual behavior plays a significant role in the etiology of cervical carcinoma. Early age at first intercourse, multiple sexual partners, poor genital hygiene, and the infrequent use of condoms are well-established risk factors for cervical carcinoma 4,14,15…”

Section: Epidemiology and Risk Factors Of Cervical Carcinomamentioning

confidence: 99%

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Carcinomas of the Uterine Cervix: Comprehensive Review With An Update on Pathogenesis, Nomenclature of Precursor and Invasive Lesions, and Differential Diagnostic Considerations

Arafah

Rashid

Tulbah³

et al. 2021

Advances in Anatomic Pathology

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Most cervical carcinomas and their related lesions are attributed to an infection by human papillomavirus (HPV). The infection usually starts in the basal cells at the squamocolumnar junction. It causes cell proliferation and maturation abnormalities along with nuclear abnormalities resulting in low-grade squamous intraepithelial lesions. An overwhelming majority of these lesions spontaneously disappear, and the infection is cleared. In a small subset of high-risk HPV infection cases, the lesions may persist and progress to high-grade squamous intraepithelial lesions. These are associated with the incorporation of the viral genome into the human genome. Some of the high-grade squamous intraepithelial lesions, over several years, progress to invasive carcinoma. Carcinomas of the cervix are usually squamous cell carcinomas (SCCs), but 20% to 25% of the cases may manifest as adenocarcinomas. Similar to SCC, adenocarcinomas may initially manifest as adenocarcinomas in situ and may progress to invasive carcinomas after a variable period of time. In the recently published World Health Organization classification of female genital tumors, SCCs, and adenocarcinomas of the cervix are divided into HPV-associated and HPV-independent tumors. This review draws on the latest terminology and the several morphologic subtypes recognized for each category.

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Section: The Cervix—histoanatomic Considerations Of Diagnostic Import...mentioning

confidence: 99%

“…2A–D). The exact origin of the reserve cells is not known, but they are probably derived from a specific embryonic cell population within the columnar epithelium 4–6…”

Section: The Cervix—histoanatomic Considerations Of Diagnostic Import...mentioning

confidence: 99%

“…Furthermore, the squamocolumnar junction recedes after menopause for variable distances into the endocervix (Fig. 1) and is no longer visible during a colposcopic examination 4–7…”

Section: The Cervix—histoanatomic Considerations Of Diagnostic Import...mentioning

confidence: 99%

Section: Epidemiology and Risk Factors Of Cervical Carcinomamentioning

confidence: 99%

See 2 more Smart Citations

Carcinomas of the Uterine Cervix: Comprehensive Review With An Update on Pathogenesis, Nomenclature of Precursor and Invasive Lesions, and Differential Diagnostic Considerations

Arafah

Rashid

Tulbah³

et al. 2021

Advances in Anatomic Pathology

View full text Add to dashboard Cite

show abstract

“…Further research is focusing on identification of viral oncopreteins E6 and E7 as markers of high-risk Papillomavirus infection in intraepithelial neoplasia [24][25][26]. PD-L1 is involved in the molecular mechanism of cervical carcinogenesis by resistance to anti-tumor immunity of intraepithelial neoplasia cells [27,28]. Most of the published studies on PD-L1 concern its identification in invasive or metastatic cancers [29][30][31]; But there are very few published studies on PD-L1 in intraepithelial neoplasia of the cervix.…”

Section: Introductionmentioning

confidence: 99%