A ferrocenyl ligand was prepared from condensation of l,l′-diacetylferrocene with 2-amino-5-methylthiazole, to give the ligand. This ligand forms 1:1 complexes with lead(II), cobalt(II), nickel(II), copper(II) and zinc(II) in good yield. Characterization of the ligand and complexes was carried out using IR, NMR, electronic absorption, magnetic susceptibility, molar conductivity and elemental analysis. Anticancer activity of the prepared ligand and its complexes against breast cancer cell line MCF-7 was determined. The anticancer activity of the new complexes was accompanied by significant increase in the activity of superoxide dismutase, with a parallel decrease in the activities of catalase and glutathione peroxidase and reduced glutathione level. Accordingly, the overproduction of free radicals allowed reactive oxygen species-mediated cancer cell death. The results suggest that the complexes possess significant anticancer activity comparable to cisplatin.
The work in this paper was devoted to investigating some nanosized iron oxide pigments prepared by microemulsion technique. The role of concentration of iron salt and surfactant (cetyltrimethylammonium bromide) on the produced iron oxide was studied. The techniques employed to characterize the samples were thermogravimetric analysis, X-ray diffractometry, transmission electron microscope, infrared spectroscopy, and diffuse reflectance spectroscopy. The results revealed that the particle size of the prepared sample using 0.2 M iron sulfate and 3.2 wt% of surfactant was in the range 7–9 nm. Increasing the concentration of either iron salt or the surfactant increased the particle size of the obtained ferric oxide. The diffuse reflectance measurements showed that the charge transfer/electron pair transition absorption peak, which is closely related to the reddish color of the oxide, was shifted to a longer wavelength (blue shift) by decreasing the dimension of the particles. The samples were tested as pigments. They showed different tints of red color and were found to be promising for applications as pigments in the field of paint manufacturing.
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