Synthesis, characterization and anticancer studies of ferrocenyl complexes containing thiazole moiety

Abstract

A ferrocenyl ligand was prepared from condensation of l,l′-diacetylferrocene with 2-amino-5-methylthiazole, to give the ligand. This ligand forms 1:1 complexes with lead(II), cobalt(II), nickel(II), copper(II) and zinc(II) in good yield. Characterization of the ligand and complexes was carried out using IR, NMR, electronic absorption, magnetic susceptibility, molar conductivity and elemental analysis. Anticancer activity of the prepared ligand and its complexes against breast cancer cell line MCF-7 was determined. The anticancer activity of the new complexes was accompanied by significant increase in the activity of superoxide dismutase, with a parallel decrease in the activities of catalase and glutathione peroxidase and reduced glutathione level. Accordingly, the overproduction of free radicals allowed reactive oxygen species-mediated cancer cell death. The results suggest that the complexes possess significant anticancer activity comparable to cisplatin.

Characterization of Eu(III) Complex for Determination of Bumetanide in Pharmaceutical Preparations and in Biological Fluids

“…In complex 1 a broad band appeared in the range 3000-3600 cm −1 assigned to the water molecules and/or to the OH stretching vibration of the ligands and/or the ethanol molecules present in the complex (22)(23)(24) . The new bands at 505 cm -1 observed in complex 1 were attributed to M-O bond in complex 1 (25)(26)(27)(28)(29)(30)(31)(32) .…”

New lanthanide complexes of 1,1`-bis[(2-thienylmethylidene)hydrazono-1-ethyl]-ferrocene and 1,1`-bis(2,3-dihydro-2-methylbenzo[d]thiazol-2-yl)ferrocene: Synthesis, characterization and antimicrobial properties

“…Yields refer to analytically pure compounds and were not optimized. 1 H and 13 C NMR was recorded on Perkin Elmer 283B and 300 MHz Varian XL-300 instruments. IR spectra were recorded on a Perkin Elmer (Spectrum 1000) Fourier-transform infrared (FT-IR) spectrometer, using KBr pellets.…”

“…The proton in the H-C=N group appeared at 8.36 ppm in the 1 H NMR spectrum. 13 C NMR spectrum (in ppm) is at 22.9, 68.8, 69.6, 73.1 (ferrocenyl), 146.6 (C=N), 121.3, 124.8, 139.8, 144.5 ppm (thiophene). In the UV-Vis spectra, a broad band centered at 456 nm was noted for the ligand.…”

“…The spectra showed that no signal at 3.5 ppm was found due to the proton of SH groups. 13 C NMR spectrum (in ppm) is at 24.8 (2 CH3), 68.4 (tert. carbon), 69.6, 72.7, 78.9 (ferrocenyl), 118.8, 127.5, 138.3, 146.5 (aromatic).…”

“…In the past few years, the versatile chemistry of ferrocene has attracted the attention of many researchers [1][2][3][4][5][6][7][8][9][10][11][12][13]. It has been used as a precursor for the preparation of coordination and biologically active compounds.…”